Fig. 6
From: Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
Strong association of calcium channel activity in NRXN1α+/− iPSC-derived neurons. a String KEGG analyses showing a significant network of VGCC association. Proteins in red are associated with calcium ion binding, in blue nodes with calcium ion transmembrane transporter activity, in green node with calcium channel activity, in yellow with voltage-gated calcium channel activity, and in purple with calcium signaling pathway. b STRING analyses of upregulated (not downregulated) genes in the NRXN1α+/− neurons showed association with “calcium ion transport” (red, 12 genes, FDR + 3.20E−03), “calcium ion transmembrane transport” (blue, 9 genes, FDR = 2.06E−02), “voltage-gated calcium channel activity” (green, 6 genes, FDR5.50E−04), calcium signaling pathway (pink, 8 genes, FDR = 4.89E−02), and “presynaptic depolarization and calcium channel opening” (light blue, 3 genes, FDR = 2.37E−02)