Fig. 5
From: Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
The pathways of calcium and ion transport activity were significantly enriched in NRXN1α+/− iPSC-derived neurons. a Volcano plot of FDR on the y-axis and Log2 fold changes on the x-axis of DEGs in NRXN1α+/− neurons. Among the 530 DEGs, 254 were downregulated (in green) and 276 upregulated (in red) with FDR < 0.05. b Bivariate clustering of samples (columns) of the 530 DEGs. The color ranges from purple (low expression) to yellow (high expression) based on TPM values (http://rpubs.com/saharava/BivariateClustering). The arrows represent the up/downregulated genes in NRXN1α+/− neurons. c The heatmap represented all genes which were linked to the 21 pathways. The color showed the most overlapped genes in dark red to non-overlapped genes in white among the pathways. d Upregulated (right) and downregulated (left) genes were shown with Log2 fold expression. The VGCCs of CACNA1A, CACNA2D1, and CACNG2/3 were shared by most pathways