Table 3 Analysis of number of subsequent children, Poisson regression analysis of rates as number of children per follow-up time
From: Reproductive stoppage in autism spectrum disorder in a population of 2.5 million individuals
Rate ratio (95% confidence interval) | ||||||
|---|---|---|---|---|---|---|
All birth orders combined | Birth order specific | |||||
Rate of children after first-born | Rate of children after second-born | |||||
ASD in any previously born | ASD in immediately previously born | ASD in first-born | ASD in first-born | ASD in second-born | ASD in both first- and second-born | |
Crude | ||||||
0.85 (0.84–0.86) | 0.98 (0.96–0.99) | 0.90 (0.89–0.91) | 1.07 (1.04–1.10) | 1.08 (1.05–1.11) | 1.07 (0.97–1.18) | |
Adjusted | ||||||
Birth order | 0.97 (0.96–0.98) | 0.94 (0.93–0.95) | NA | NA | NA | NA |
Maternal agea | 0.91 (0.9–0.92) | 1.00 (0.99–1.01) | 0.94 (0.93–0.95) | 1.09 (1.06–1.12) | 1.11 (1.08–1.14) | 1.10 (1.00–1.20) |
Birth period | 0.87 (0.87–0.88) | 1.04 (1.02–1.05) | 0.95 (0.94–0.97) | 1.07 (1.05–1.11) | 1.14 (1.11–1.18) | 1.11 (1.00–1.22) |
Sex | 0.85 (0.84–0.86) | 0.98 (0.96–0.99) | 0.90 (0.89–0.91) | 1.07 (1.04–1.10) | 1.08 (1.05–1.11) | 1.07 (0.97–1.18) |
Paternal age | 0.88 (0.87–0.89) | 0.97 (0.96–0.99) | 0.91 (0.90–0.92) | 1.08 (1.05–1.11) | 1.06 (1.03–1.09) | 1.09 (0.99–1.20) |
Maternal education | 0.87 (0.87–0.88) | 1.00 (0.99–1.01) | 0.92 (0.91–0.93) | 1.11 (1.08–1.14) | 1.11 (1.08–1.14) | 1.10 (1.00–1.21) |
All of abovea | 1.04 (1.03–1.05) | 1.02 (1.01–1.03) | 0.98 (0.96–0.99) | 1.11 (1.08–1.14) | 1.15 (1.12–1.18) | 1.14 (1.04–1.24) |