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Table 3 Analysis of number of subsequent children, Poisson regression analysis of rates as number of children per follow-up time

From: Reproductive stoppage in autism spectrum disorder in a population of 2.5 million individuals

 Rate ratio (95% confidence interval)
 All birth orders combinedBirth order specific
   Rate of children after first-bornRate of children after second-born
 ASD in any previously bornASD in immediately previously bornASD in first-bornASD in first-bornASD in second-bornASD in both first- and second-born
Crude
 0.85 (0.84–0.86)0.98 (0.96–0.99)0.90 (0.89–0.91)1.07 (1.04–1.10)1.08 (1.05–1.11)1.07 (0.97–1.18)
Adjusted
 Birth order0.97 (0.96–0.98)0.94 (0.93–0.95)NANANANA
 Maternal agea0.91 (0.9–0.92)1.00 (0.99–1.01)0.94 (0.93–0.95)1.09 (1.06–1.12)1.11 (1.08–1.14)1.10 (1.00–1.20)
 Birth period0.87 (0.87–0.88)1.04 (1.02–1.05)0.95 (0.94–0.97)1.07 (1.05–1.11)1.14 (1.11–1.18)1.11 (1.00–1.22)
 Sex0.85 (0.84–0.86)0.98 (0.96–0.99)0.90 (0.89–0.91)1.07 (1.04–1.10)1.08 (1.05–1.11)1.07 (0.97–1.18)
 Paternal age0.88 (0.87–0.89)0.97 (0.96–0.99)0.91 (0.90–0.92)1.08 (1.05–1.11)1.06 (1.03–1.09)1.09 (0.99–1.20)
 Maternal education0.87 (0.87–0.88)1.00 (0.99–1.01)0.92 (0.91–0.93)1.11 (1.08–1.14)1.11 (1.08–1.14)1.10 (1.00–1.21)
 All of abovea1.04 (1.03–1.05)1.02 (1.01–1.03)0.98 (0.96–0.99)1.11 (1.08–1.14)1.15 (1.12–1.18)1.14 (1.04–1.24)
  1. Poisson model with number of following children as outcome and time of follow-up as offset term. Mothers are assumed to not be able to have children after age 54
  2. NA not applicable, ASD autism spectrum disorder
  3. aAnalysis adjusted for different baseline rates of children in different maternal age intervals (< 20, 20–24, 25–29, 30–34, 35–39, 40–44, 45–54).