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Fig. 5 | Molecular Autism

Fig. 5

From: Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism

Fig. 5

ClustalW multiple alignment of partial protein sequences of PHF21A orthologs. The position of the residue affected by the missense mutation of PHF21A in patient 2 is marked by an arrow and a red letter in the corresponding segments of the multiple alignment. The amino acid residues that differ from the sequence of the human PHF21A protein are indicated in violet, and the sequence of the AT Hook domain (aa 425–437 in NP_001095272.1, UniProtKB-Q96BD5) is indicated in green. The mutated amino acid glycine is evolutionarily fully conserved in all nine available PHF21A orthologs

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Molecular Autism

ISSN: 2040-2392