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Table 2 Self-reported neuropsychiatric diagnoses

From: Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry

  3q29 deletion syndrome Control p value; 3q29Del vs. control
  Total Male Female Total Male Female  
GDD/MR (n, %)        < 2.20E− 16
 Yes 55 (59.1%) 31 (57.4%) 24 (61.5%) 1.14%* 1.48%* 0.90%*  
 No 38 (40.9%) 23 (42.6%) 15 (38.5%) 64 (100%) 33 (100%) 31 (100%)  
ASD (n, %)        < 2.20E− 16
 Yes 27 (29.0%) 20 (37.0%) 7 (17.9%) 1.47%* 2.34%* 0.52%*  
 No 66 (71.0%) 34 (63.0%) 32 (82.1%) 64 (100%) 33 (100%) 31 (100%)  
Anxiety (n, %)        0.001
 Yes 26 (28.0%) 15 (27.8%) 11 (28.2%) 4 (6.2%) 2 (6.1%) 2 (6.5%)  
 No 67 (72.0%) 39 (72.2%) 28 (71.8%) 60 (93.8%) 31 (93.9%) 29 (93.5%)  
Bipolar/Manic Depression (n. %)        0.146
 Yes 4 (4.3%) 2 (3.7%) 2 (5.1%) 0 (0%) 0 (0%) 0 (0%)  
 No 89 (95.7%) 52 (96.3%) 37 (94.9%) 64 (100%) 33 (100%) 31 (100%)  
Conduct Disorder (n, %)        1.00
 Yes 1 (1.1%) 1 (1.9%) 0 (0%) 0 (0%) 0 (0%) 0 (0%)  
 No 92 (98.9%) 53 (98.1%) 39 (100%) 64 (100%) 33 (100%) 31 (100%)  
Depression (n, %)        1.00
 Yes 6 (6.5%) 2 (3.7%) 4 (10.3%) 4 (6.2%) 4 (12.1%) 0 (0%)  
 No 87 (93.5%) 52 (96.3%) 35 (89.7%) 60 (93.8%) 29 (87.9%) 31 (100%)  
Oppositional Defiant Disorder (n, %)        0.271
 Yes 3 (3.2%) 2 (3.7%) 1 (2.6%) 0 (0%) 0 (0%) 0 (0%)  
 No 90 (96.8%) 52 (96.3%) 38 (97.4%) 64 (100%) 33 (100%) 31 (100%)  
Panic Attacks (n, %)        0.045
 Yes 12 (12.9%) 9 (16.7%) 4 (10.3%) 2 (3.2%) 0 (0%) 2 (6.5%)  
 No 81 (87.1%) 45 (83.3%) 35 (89.7%) 62 (96.8%) 33 (100%) 29 (93.5%)  
Schizophrenia (n, %)        0.146
 Yes 4 (4.3%) 1 (1.9%) 3 (7.7%) 0 (0%) 0 (0%) 0 (0%)  
 No 89 (95.7%) 53 (98.1%) 36 (92.3%) 64 (100%) 33 (100%) 31 (100%)  
  1. Characteristics of self-reported neuropsychiatric diagnoses in study participants with 3q29Del and controls. Asterisks indicate where 3q29Del was compared to general population prevalence values [35, 36]. p values were calculated with one-sample proportion test with Yates’ continuity correction when comparing to population prevalence and Fisher’s exact test when comparing to controls