| |
3q29 deletion syndrome
|
Control
|
p value; 3q29Del vs. control
|
|---|
| |
Total
|
Male
|
Female
|
Total
|
Male
|
Female
| |
|---|
|
GDD/MR (n, %)
| | | | | | |
< 2.20E− 16
|
|
Yes
|
55 (59.1%)
|
31 (57.4%)
|
24 (61.5%)
|
1.14%*
|
1.48%*
|
0.90%*
| |
|
No
|
38 (40.9%)
|
23 (42.6%)
|
15 (38.5%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
|
ASD (n, %)
| | | | | | |
< 2.20E− 16
|
|
Yes
|
27 (29.0%)
|
20 (37.0%)
|
7 (17.9%)
|
1.47%*
|
2.34%*
|
0.52%*
| |
|
No
|
66 (71.0%)
|
34 (63.0%)
|
32 (82.1%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
|
Anxiety (n, %)
| | | | | | |
0.001
|
|
Yes
|
26 (28.0%)
|
15 (27.8%)
|
11 (28.2%)
|
4 (6.2%)
|
2 (6.1%)
|
2 (6.5%)
| |
|
No
|
67 (72.0%)
|
39 (72.2%)
|
28 (71.8%)
|
60 (93.8%)
|
31 (93.9%)
|
29 (93.5%)
| |
|
Bipolar/Manic Depression (n. %)
| | | | | | |
0.146
|
|
Yes
|
4 (4.3%)
|
2 (3.7%)
|
2 (5.1%)
|
0 (0%)
|
0 (0%)
|
0 (0%)
| |
|
No
|
89 (95.7%)
|
52 (96.3%)
|
37 (94.9%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
|
Conduct Disorder (n, %)
| | | | | | |
1.00
|
|
Yes
|
1 (1.1%)
|
1 (1.9%)
|
0 (0%)
|
0 (0%)
|
0 (0%)
|
0 (0%)
| |
|
No
|
92 (98.9%)
|
53 (98.1%)
|
39 (100%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
|
Depression (n, %)
| | | | | | |
1.00
|
|
Yes
|
6 (6.5%)
|
2 (3.7%)
|
4 (10.3%)
|
4 (6.2%)
|
4 (12.1%)
|
0 (0%)
| |
|
No
|
87 (93.5%)
|
52 (96.3%)
|
35 (89.7%)
|
60 (93.8%)
|
29 (87.9%)
|
31 (100%)
| |
|
Oppositional Defiant Disorder (n, %)
| | | | | | |
0.271
|
|
Yes
|
3 (3.2%)
|
2 (3.7%)
|
1 (2.6%)
|
0 (0%)
|
0 (0%)
|
0 (0%)
| |
|
No
|
90 (96.8%)
|
52 (96.3%)
|
38 (97.4%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
|
Panic Attacks (n, %)
| | | | | | |
0.045
|
|
Yes
|
12 (12.9%)
|
9 (16.7%)
|
4 (10.3%)
|
2 (3.2%)
|
0 (0%)
|
2 (6.5%)
| |
|
No
|
81 (87.1%)
|
45 (83.3%)
|
35 (89.7%)
|
62 (96.8%)
|
33 (100%)
|
29 (93.5%)
| |
|
Schizophrenia (n, %)
| | | | | | |
0.146
|
|
Yes
|
4 (4.3%)
|
1 (1.9%)
|
3 (7.7%)
|
0 (0%)
|
0 (0%)
|
0 (0%)
| |
|
No
|
89 (95.7%)
|
53 (98.1%)
|
36 (92.3%)
|
64 (100%)
|
33 (100%)
|
31 (100%)
| |
- Characteristics of self-reported neuropsychiatric diagnoses in study participants with 3q29Del and controls. Asterisks indicate where 3q29Del was compared to general population prevalence values [35, 36]. p values were calculated with one-sample proportion test with Yates’ continuity correction when comparing to population prevalence and Fisher’s exact test when comparing to controls
