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Table 2 Self-reported neuropsychiatric diagnoses

From: Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry

 

3q29 deletion syndrome

Control

p value; 3q29Del vs. control

 

Total

Male

Female

Total

Male

Female

 

GDD/MR (n, %)

      

< 2.20E− 16

 Yes

55 (59.1%)

31 (57.4%)

24 (61.5%)

1.14%*

1.48%*

0.90%*

 

 No

38 (40.9%)

23 (42.6%)

15 (38.5%)

64 (100%)

33 (100%)

31 (100%)

 

ASD (n, %)

      

< 2.20E− 16

 Yes

27 (29.0%)

20 (37.0%)

7 (17.9%)

1.47%*

2.34%*

0.52%*

 

 No

66 (71.0%)

34 (63.0%)

32 (82.1%)

64 (100%)

33 (100%)

31 (100%)

 

Anxiety (n, %)

      

0.001

 Yes

26 (28.0%)

15 (27.8%)

11 (28.2%)

4 (6.2%)

2 (6.1%)

2 (6.5%)

 

 No

67 (72.0%)

39 (72.2%)

28 (71.8%)

60 (93.8%)

31 (93.9%)

29 (93.5%)

 

Bipolar/Manic Depression (n. %)

      

0.146

 Yes

4 (4.3%)

2 (3.7%)

2 (5.1%)

0 (0%)

0 (0%)

0 (0%)

 

 No

89 (95.7%)

52 (96.3%)

37 (94.9%)

64 (100%)

33 (100%)

31 (100%)

 

Conduct Disorder (n, %)

      

1.00

 Yes

1 (1.1%)

1 (1.9%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

 

 No

92 (98.9%)

53 (98.1%)

39 (100%)

64 (100%)

33 (100%)

31 (100%)

 

Depression (n, %)

      

1.00

 Yes

6 (6.5%)

2 (3.7%)

4 (10.3%)

4 (6.2%)

4 (12.1%)

0 (0%)

 

 No

87 (93.5%)

52 (96.3%)

35 (89.7%)

60 (93.8%)

29 (87.9%)

31 (100%)

 

Oppositional Defiant Disorder (n, %)

      

0.271

 Yes

3 (3.2%)

2 (3.7%)

1 (2.6%)

0 (0%)

0 (0%)

0 (0%)

 

 No

90 (96.8%)

52 (96.3%)

38 (97.4%)

64 (100%)

33 (100%)

31 (100%)

 

Panic Attacks (n, %)

      

0.045

 Yes

12 (12.9%)

9 (16.7%)

4 (10.3%)

2 (3.2%)

0 (0%)

2 (6.5%)

 

 No

81 (87.1%)

45 (83.3%)

35 (89.7%)

62 (96.8%)

33 (100%)

29 (93.5%)

 

Schizophrenia (n, %)

      

0.146

 Yes

4 (4.3%)

1 (1.9%)

3 (7.7%)

0 (0%)

0 (0%)

0 (0%)

 

 No

89 (95.7%)

53 (98.1%)

36 (92.3%)

64 (100%)

33 (100%)

31 (100%)

 
  1. Characteristics of self-reported neuropsychiatric diagnoses in study participants with 3q29Del and controls. Asterisks indicate where 3q29Del was compared to general population prevalence values [35, 36]. p values were calculated with one-sample proportion test with Yates’ continuity correction when comparing to population prevalence and Fisher’s exact test when comparing to controls