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Fig. 5 | Molecular Autism

Fig. 5

From: CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes

Fig. 5

RNA sequencing of the BLA identifies molecular pathways underlying fear conditioning response, neuronal structure, and function. a Analysis of RNA sequencing from the BLA identified 177 differentially expressed genes (82 downregulated and 95 upregulated) when comparing CYFIP1 OE mice to their WT litter mates. b A list of the top 5 significant GO-terms derived from analysis of DE genes and their Z-scores. c Dendrogram produced from WGCNA analysis of the BLA transcriptome resulting in 13 modules. d R-squared values and directionality for the 8 modules significantly associated with genotype (fdr < 0.1), blue (R2 = 0.97), red (R2 = 0.72), salmon (R2 = 0.58), brown (R2 = 0.50), green-yellow (R2 = 0.43), tan (R2 = − 0.33), purple (R2 = − 0.54), and turquoise (R2 = − 0.96). e Cell type enrichment analysis for the significantly expressed modules. The numbers represent the odds ratio. f Enrichment of genes in each module associated with Dup15q, ASD, schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). The numbers represent odds ratio. g A list of the top 3 significant GO-terms for each module and their Z-scores. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.005

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