Fig. 5From: CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypesRNA sequencing of the BLA identifies molecular pathways underlying fear conditioning response, neuronal structure, and function. a Analysis of RNA sequencing from the BLA identified 177 differentially expressed genes (82 downregulated and 95 upregulated) when comparing CYFIP1 OE mice to their WT litter mates. b A list of the top 5 significant GO-terms derived from analysis of DE genes and their Z-scores. c Dendrogram produced from WGCNA analysis of the BLA transcriptome resulting in 13 modules. d R-squared values and directionality for the 8 modules significantly associated with genotype (fdr < 0.1), blue (R2 = 0.97), red (R2 = 0.72), salmon (R2 = 0.58), brown (R2 = 0.50), green-yellow (R2 = 0.43), tan (R2 = − 0.33), purple (R2 = − 0.54), and turquoise (R2 = − 0.96). e Cell type enrichment analysis for the significantly expressed modules. The numbers represent the odds ratio. f Enrichment of genes in each module associated with Dup15q, ASD, schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). The numbers represent odds ratio. g A list of the top 3 significant GO-terms for each module and their Z-scores. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.005Back to article page