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Fig. 3 | Molecular Autism

Fig. 3

From: Retinal alterations in a pre-clinical model of an autism spectrum disorder

Fig. 3

VPA animals have significantly smaller a-waves than CTR. a Semi-log plot of a-wave mean amplitudes obtained at each light intensity for CTR (open symbols, n = 8 animals, 15 eyes) and VPA animals (solid symbols, n = 6 animals, 12 eyes). The solid lines are Hill fits to the data points. The a-wave amplitudes of the VPA group are smaller, especially at higher stimulus intensities. b The mean maximal a-wave amplitude (Vmax) of VPA is smaller than that of CTR mice (***p < 0.001). c, d The mean semi-saturation constant (k) and slope (n) of the a-wave intensity-response relationship for CTR vs. VPA are not significantly different. e Semi-log plot of b-wave mean amplitudes obtained at each light intensity for CTR (open symbols, same n as in (ad)) and VPA animals (solid symbols, same n as in (ad)). The solid lines are Hill fits to the data points. Although b-waves are slightly smaller in the VPA group, the difference did not reach statistical significance. fh The mean maximal b-wave amplitude (Vmax), semi-saturation constant (k), and slope (n) of the b-wave intensity-response relationship for CTR vs. VPA are not significantly different. For all panels, error bars are SEM. i Amplitudes of the b-wave vs. the corresponding a-wave amplitude in the same trace for CTR (open symbols) and VPA mice (solid symbols). Solid lines are linear fits to the data (CTR: adjusted R2 = 0.64; VPA: adjusted R2 = 0.66). j The distributions of the ratios between the b-wave and a-wave in the same trace for CTR (open symbols) and VPA mice (solid symbols) are very similar. k Cumulative distribution of the ratios between the b-wave and a-wave in the same trace for CTR (open symbols) and VPA mice (solid symbols). Dashed arrows indicate the median of each group (same color code as the respective symbols)

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