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Table 2 Restored or ameliorated phenotypes in Shank3 mouse models displaying the targeted domain(s), the experimental paradigms, and the drug name

From: A multifaceted approach for analyzing complex phenotypic data in rodent models of autism

Domain Phenoterm Experimental paradigm Effect Agent Citation
All Reward reinforced choice behavior Operant conditioning paradigm Ameliorated CDPPB [49]
Protein localization: synapse Western blot: striatum Ameliorated
Synaptic plasticity: striatal LTD Whole-cell patch clamp Restored
General locomotor activity Open field test Restored MPEP
Self-grooming: perseveration Grooming behavior assessments Ameliorated
ANK Motor coordination and balance Accelerating rotarod test Restored IGF-1(high dose) [50]
Neuroreceptor activity Whole-cell patch clamp Restored
Synaptic plasticity: hippocampal LTP Restored
Neuroreceptor activity Restored Peptide derivative of IGF-1
Synaptic plasticity: hippocampal LTP Restored
PRO Synaptic transmission: excitatory Whole-cell patch clamp Ameliorated Constitutively active Rac1 [51]
Social approach Three-chamber social approach test Ameliorated
Cytoskeletal organization Western blot: actin and F-actin levels Restored P-cofilin peptide (high dose)
Self-grooming: perseveration Grooming behavior assessments Restored
Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Whole-cell patch clamp Restored P-cofilin peptide (high dose)#
Synaptic transmission: excitatory Restored
Social approach Three-chamber social approach test Restored
Protein phosphorylation Western blot Restored TG003, CLK2 inhibitor [52]
Self-grooming: perseveration Grooming behavior assessments Ameliorated
Social approach Three-chamber social approach test Restored
  1. #P-cofilin delivered by intravenous injection or stereotaxic injection into the prefrontal cortex, administered to different groups of mice, and tested separately