Table 2 Restored or ameliorated phenotypes in Shank3 mouse models displaying the targeted domain(s), the experimental paradigms, and the drug name
From: A multifaceted approach for analyzing complex phenotypic data in rodent models of autism
Domain | Phenoterm | Experimental paradigm | Effect | Agent | Citation |
|---|---|---|---|---|---|
All | Reward reinforced choice behavior | Operant conditioning paradigm | Ameliorated | CDPPB | [49] |
Protein localization: synapse | Western blot: striatum | Ameliorated | |||
Synaptic plasticity: striatal LTD | Whole-cell patch clamp | Restored | |||
General locomotor activity | Open field test | Restored | MPEP | ||
Self-grooming: perseveration | Grooming behavior assessments | Ameliorated | |||
ANK | Motor coordination and balance | Accelerating rotarod test | Restored | IGF-1(high dose) | [50] |
Neuroreceptor activity | Whole-cell patch clamp | Restored | |||
Synaptic plasticity: hippocampal LTP | Restored | ||||
Neuroreceptor activity | Restored | Peptide derivative of IGF-1 | |||
Synaptic plasticity: hippocampal LTP | Restored | ||||
PRO | Synaptic transmission: excitatory | Whole-cell patch clamp | Ameliorated | Constitutively active Rac1 | [51] |
Social approach | Three-chamber social approach test | Ameliorated | |||
Cytoskeletal organization | Western blot: actin and F-actin levels | Restored | P-cofilin peptide (high dose) | ||
Self-grooming: perseveration | Grooming behavior assessments | Restored | |||
Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission | Whole-cell patch clamp | Restored | P-cofilin peptide (high dose)# | ||
Synaptic transmission: excitatory | Restored | ||||
Social approach | Three-chamber social approach test | Restored | |||
Protein phosphorylation | Western blot | Restored | TG003, CLK2 inhibitor | [52] | |
Self-grooming: perseveration | Grooming behavior assessments | Ameliorated | |||
Social approach | Three-chamber social approach test | Restored |