Molecular Autism

Table 5 Odds ratio and 95% confidence intervals for ASD according to PFAS in amniotic fluid

From: Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

	Crude			Adjusted^a
	n (cases/controls)	OR (95% CI)	p	n (cases/controls)	OR (95% CI)	p	FDR (q_value)
PFOS (ng/mL)	37/51	0.460 (0.230, 0.921)	0.028	37/50	0.410 (0.174, 0.967)	0.042	0.437
PFOSA (ng/mL)	37/51	0.913 (0.797, 1.046)	0.189	37/50	0.918 (0.789, 1.069)	0.272	0.565
PFOA (ng/mL)	37/51	0.335 (0.044, 2.559)	0.292	37/50	0.164 (0.013, 2.126)	0.167	0.437
∑PFSA (ng/mL)	37/51	0.894 (0.777, 1.028)	0.115	37/50	0.900 (0.771, 1.049)	0.178	0.437
∑PFCA (ng/mL)	37/51	0.299 (0.041, 2.160)	0.232	37/50	0.150 (0.013, 1.760)	0.131	0.437
∑PFSA+∑PFCA (ng/mL)	37/51	0.894 (0.779, 1.025)	0.107	37/50	0.896 (0.770, 1.044)	0.158	0.437

FDR (q_value) false discovery rate. Italicized values indicate statistically significant (p < 0.05 and FDR q_value < 0.25)
^aAdjusted for children’s birth year, children’s sex, mother age at delivery, father age at child birth, birth weight, gestational week at sampling, gestational age at birth, Apgar score, parity, and congenital malformation

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ISSN: 2040-2392

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