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Fig. 3 | Molecular Autism

Fig. 3

From: Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

Fig. 3

Quantitative variation in ASD-like phenotypes and genetic mapping in CC mice. a Histograms of grooming, social interaction, and short-term and long-term social discrimination. b Grooming, social interaction, and short-term and long-term social discrimination from up to 53 CC lines. Plots are expressed as mean ± SEM, with CC lines ordered along the x-axis by mean (one-way ANOVA P = 2.8 × 10−5, P = 2.8 × 10−8, P = 0.0035, and P = 0.33; one-way ANOVA after correction for age, batch, and origin P = 0.0027, P = 2.6 × 10−5, P = 0.18, and P = 0.31). c Genome scans for grooming, social interaction, and short-term and long-term social discrimination. No QTLs were detected. d Histograms of stereotyped exploratory patterns. e Stereotyped exploratory patterns obtained from CC lines. Plots are expressed as mean ± SEM, with CC lines ordered along the x-axis by mean per phenotype (one-way ANOVA P = 1.6 × 10−14; one-way ANOVA after correction for age, batch, and origin P = 3.3 × 10−7). f Genome scans for stereotyped exploratory patterns. QTLs for stereotyped exploratory patterns were detected on chromosome 2 (permuted P = 0.012) and chromosome 12 (permuted P = 0.003). Dashed lines represent genome-wide permuted P < .05, 0.1, and 0.5

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