Skip to main content

Advertisement

Fig. 4 | Molecular Autism

Fig. 4

From: Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

Fig. 4

Pharmacological properties of four indenoisoquinoline derivatives in unsilencing paternal Ube3a-YFP in vitro. a Dose dependence of four indenoisoquinoline derivatives and topotecan in unsilencing of paternal UBE3A-YFP (n = 4/group). Estimated potencies and efficacies of the drugs are summarized in Table 1. b Dose-dependent cytotoxicities of four indenoisoquinoline derivatives and topotecan (n = 4/group). Estimated LC50 values are summarized in Table 1

Back to article page