Fig. 3

Global gene expression signatures for Dup15q and Angelman syndromes. a Unsupervised clustering heatmap signatures in DPSC neuronal cultures for 15q Duplication vs controls (left), AS deletion vs controls (middle), and AS deletion vs 15q Duplication (right). Note that ~ 2/3 of the transcripts went down in the DPSC neuronal cultures in 15q Duplication vs control and approximately 50% of the transcripts decreased in duplication vs AS deletion DPSC-neurons. b STRING analysis of significantly different transcripts in DPSC neuronal cultures from 15q Duplication vs control analysis. Colors of the circles represent the Log2 fold change in gene expression. Note the strong decrease in FOXO1 gene expression and the relationship of this protein to other proteins in the significant network. Also note that three cytokines were significantly elevated at the transcript level (CCL7, MMP1, and MMP3). c Venn diagram showing the significant overlap among genes upregulated in Dup15q postmortem cortex, idiopathic ASD postmortem cortex, and the 1500 most significantly upregulated genes in DPSC neurons