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Fig. 4 | Molecular Autism

Fig. 4

From: Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Fig. 4

Summary of regional phenotypes of excitation/inhibition imbalance in the mouse model of neurofibromatosis type 1. The Nf1 +/− model shows GABAergic changes in a region-dependent way. The synaptic phenotype in hippocampus is characterized by GABA(A) R disproportionate increases while in the prefrontal cortex and striatum it is characterized by GABA/glutamate ratio increases. In spite of the differences in synaptic phenotype in these brain regions, the physiological phenotype is similar with converging increases of sIPSCs relative to sEPSCs resulting in increased inhibitory drive. Abbreviation: GABA, γ-aminobutyric acid; GLU, glutamate; sEPSCs, spontaneous excitatory post-synaptic currents; sIPSCs, spontaneous inhibitory post-synaptic currents

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Molecular Autism

ISSN: 2040-2392