Fig. 2

VPA disrupts cellular growth, neural development, and immune function in amygdala gene pathways from P10 to 21. Heat maps of median normalized gene expression in saline (a) and VPA (b) animals from P10 to 21 depict log2 fold changes of genes with q < 0.05. Differential expression scatterplots and transcript histograms of individual genes from P10 to 21 in saline (c) and VPA (d) exposed animals, where red and blue points represent genes with over 2-fold up- or down-regulation changes, respectively, in log expression across time. Ingenuity Pathway Analyses (IPA) were run on genes with significant (q < 0.05) effects of time in saline (n = 1498) and VPA (n = 1682 VPA) samples. Pathways with predicted activation changes from P10 to P21 exclusive to either saline (e) or VPA (f). Canonical pathways and diseases and functions categories with predicted activation or inhibition were broadly categorized into the following groups: cellular development and growth; nervous system development and function; immune system, cancer, disease; cell/organismal death; metabolism; and developmental, neurological, or psychological disorder