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Fig. 3 | Molecular Autism

Fig. 3

From: Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome

Fig. 3

c-Fos staining in Fmr1 mice. The intensity of c-Fos staining (ac) and the number of c-Fos-positive cells (df) in the lateral amygdala (a, d), medial amygdala (b, e), and prelimbic cortex (c, f). Insets show anatomical regions assessed shaded in gray. Representative staining for c-Fos in the PLC of (g) wildtype mouse exposed to a non-social stimulus, (h) wildtype mouse exposed to a social stimulus, (l) Fmr1 KO mouse exposed to a non-social stimulus, and (j) Fmr1 KO mouse exposed to a social stimulus. The number of c-Fos-positive cells was compared between brain regions for each subject. There was a significant positive correlation between LA and MA, and a significant negative correlation between each amygdalar region and the PLC (k)

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