Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes

Table 1 Mouse demographics and experimental parameters used to analyzed neuroanatomy in each experimental group

Exp. group	Allele	Background	Sex	Age	WT	Mut	Imaging
Mecp2^{308 /y[B6,P200]}	Mecp2^tm1Hzo	C57BL/6J	M	200	9	10	100G/cm,TR=325ms,TEeff=40ms,32 μm
Mecp2^{308 /x[B6,P200]}	Mecp2^tm1Hzo	C57BL/6J	F	200	11	12	100G/cm,TR=325ms,TEeff=40ms,32 μm
Mecp2^{308 /308[B6,P200]}	Mecp2^tm1Hzo	C57BL/6J	F	200	11	11	100G/cm,TR=325ms,TEeff=40ms,32 μm
Mecp2^{308 /y[B6,P60]}	Mecp2^tm1Hzo	C57BL/6J	M	60	9	10	12G/cm,TR=2000ms,TEeff=42ms,56 μm
Mecp2^{308 /y[B6,P42]}	Mecp2^tm1Hzo	C57BL/6J	M	42	5	5	Weight calculations
Mecp2^{NULL/y[129,P60]}	Mecp2^tm1.1Bird	129 /SvEvTac	M	60	13	9	30G/cm,TR=350ms,TEeff=30ms,40 μm
Mecp2^{STOP/y[B6,P60]}	Mecp2^tm2Bird	C57BL/6J	M	60	10	13	30G/cm,TR=350ms,TEeff=30ms,40 μm
Mecp2^{STOP/x[B6,P200]}	Mecp2^tm2Bird	C57BL/6J	F	200	11	11	30G/cm,TR=350ms,TEeff=30ms,40 μm
Mecp2^{STOP/y[Hyb,P60]}	Mecp2^tm2Bird	C57 /CBA	M	60	14	15	30G/cm,TR=350ms,TEeff=30ms,40 μm

Mecp2 allele (Mecp2^tm1Hzo, Mecp2^tm1.1Bird, Mecp2^tm2Bird), mouse background (C57BL/6J, 129/SvEvTac, C57/CBA hybrid), sex (male, female), age (days), sample size for WT and mutant mice (mut), gradient strength (G/cm), repetition time (TR), effective echo time (TEeff), and final image resolution (μm) for each experimental group. Experimental groups were named based on the Mecp2 allele, background and age

ISSN: 2040-2392