Fig. 4

Neuroanatomical differences between mutant and WT mice carrying the Mecp2^tm1.1Bird and Mecp2^tm2Bird mutations. Significant voxelwise differences (5% FDR-corrected) were overlaid on the final nonlinear average for a Mecp2^{NULL/y[129,P60]}; t = 2.15, b Mecp2^{STOP/y[B6,P60]}; t = 2.16, c Mecp2^{STOP/y[Hyb,P60]}; t = 2.09, and d Mecp2^{STOP/x[B6,P200]}; t=2.15 experimental groups. The magnitude of the effects is shown as a percent difference; Mutants < WT (dark blue to light blue). Percent difference in volume across the 159 segmented structures are shown in (e)., with white barsindicating no difference and blue indicating smaller in mutants compared to WT