|
Androgensa
|
Older affected sibling’s sex
|
Outcomes
|
|---|
| | |
12-month AOSI
|
36-month SRS
|
|---|
| | |
Beta
|
95% CI
|
P
|
P
b
|
Beta
|
95% CI
|
P
|
P
b
|
|---|
|
ln(T)
|
Female (n = 22)
|
0.91
|
(0.20,1.63)
|
0.02
|
0.008
|
0.61
|
(0.27,0.94)
|
0.001
|
0.006
|
| |
Male (n = 115)
|
0.08
|
(−0.16, 0.32)
|
0.50
| |
−0.08
|
(−0.30,0.14)
|
0.47
| |
|
ln(A4)
|
Female (n = 22)
|
0.22
|
(−1.88,2.33)
|
0.82
|
0.84
|
1.10
|
(−0.07,2.28)
|
0.06
|
0.06
|
| |
Male (n = 115)
|
0.05
|
(−0.22,0.33)
|
0.70
| |
−0.23
|
(−0.48,0.02)
|
0.07
| |
|
ln(DHEA)
|
Female (n = 22)
|
0.39
|
(−0.40,1.18)
|
0.32
|
0.36
|
0.18
|
(−0.26,0.61)
|
0.40
|
0.68
|
| |
Male (n = 115)
|
0.02
|
(−0.20,0.24)
|
0.86
| |
−0.06
|
(−0.26,0.14)
|
0.57
| |
-
ln natural log transformed
-
aRobust regression models of loge-transformed testosterone (T), androstenedione (A4), and dehydroepiandrostenedione (DHEA) with total loge (AOSI + 1) and loge (SRS raw) adjusted for infant sex, gestational age and maternal age. Outcome measures are 12-month Autism Observation Scales for Infants (AOSI) total score and 36-month Social Responsiveness Scale (SRS) total raw score
-
bInteraction P value comes from a model including both subject sexes including covariates, hormone variable, subject sex, older affected sibling sex and older affected sibling sex hormone interaction
