Fig. 4

Changes observed in hippocampal and cerebellar synapses using mass spectrometry and microscopy studies. In the hippocampus (above), significant changes were observed for ATPases and a significant decrease of GABA receptor proteins. Furthermore, the microscopy studies indicated decreased synaptic vesicle release in hippocampal neurons. This might indicate decreased excitatory synaptic transmission in the hippocampus. A significant increase of ATPases, GABA and glutamate receptors and synaptic vesicle proteins were observed in cerebellar synapses (below). This increase in synaptic activity was also supported by the microscopy studies, in which cerebellar neurons show an increase of synaptic vesicle dynamics, suggesting an increased inhibitory output from the cerebellum