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Table 2 Integration of human neocortex/hippocampus developmental genes and mouse differentially expressed genes in culture and brain

From: Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

Case/cluster H0 H1 H2 Case/cluster C0 C1 C2
All genes 5808 4242 3780 All genes 5572 4217 4041
% 42 31 27 % 40 30 29
Differentially expressed genes in cultured cells      
 Hippo culture KO/WT down 239 200 260 Cortex culture KO/WT down 428 461 408
 % 34 29 37 % 33 36 31
 Hippo culture KO/WT up 821 191 298 Cortex culture KO/WT up 732 268 168
 % 63 15 23 % 63 23 14
 Hippo culture KO/WT combined 1060 391 558 Cortex culture KO/WT combined 1160 729 576
 % 53 19 28 % 47 30 23
Differentially expressed genes in primary brain tissue     
 Hippo brain KO/WT down 92 126 65 Cortex brain KO/WT down 102 52 57
 % 32.5 44.5 23 % 48.3 24.6 27.1
 Hippo brain KO/WT up 61 71 39 Cortex brain KO/WT up 96 81 162
 % 35.7 41.5 22.8 % 28.3 24 47.7
 Hippo brain KO/WT combined 153 197 104 Cortex brain KO/WT combined 198 133 219
 % 33.7 43.4 22.9 % 36 24.2 39.8