Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

Table 2 Integration of human neocortex/hippocampus developmental genes and mouse differentially expressed genes in culture and brain

Case/cluster	H0	H1	H2	Case/cluster	C0	C1	C2
All genes	5808	4242	3780	All genes	5572	4217	4041
%	42	31	27	%	40	30	29
Differentially expressed genes in cultured cells
Hippo culture KO/WT down	239	200	260	Cortex culture KO/WT down	428	461	408
%	34	29	37	%	33	36	31
Hippo culture KO/WT up	821	191	298	Cortex culture KO/WT up	732	268	168
%	63	15	23	%	63	23	14
Hippo culture KO/WT combined	1060	391	558	Cortex culture KO/WT combined	1160	729	576
%	53	19	28	%	47	30	23
Differentially expressed genes in primary brain tissue
Hippo brain KO/WT down	92	126	65	Cortex brain KO/WT down	102	52	57
%	32.5	44.5	23	%	48.3	24.6	27.1
Hippo brain KO/WT up	61	71	39	Cortex brain KO/WT up	96	81	162
%	35.7	41.5	22.8	%	28.3	24	47.7
Hippo brain KO/WT combined	153	197	104	Cortex brain KO/WT combined	198	133	219
%	33.7	43.4	22.9	%	36	24.2	39.8

ISSN: 2040-2392