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Table 2 Autism symptom levels in non-ASD, non-ASD with HLDAS, and ASD-affected children by family incidence type

From: Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families

 

Non-ASD siblings

Non-ASD siblings with HLDAS

ASD siblings

Family incidence type by diagnostic group

Single incidence families

Multiple incidence families

Single incidence families

Multiple incidence families

Single incidence families

Multiple incidence families

Χ 2 (p)

M (SD)

M (SD)

M (SD)

M (SD)

M (SD)

M (SD)

 

SRS

 Total raw score

19.7 (19.4)

27.9 (27.3)

41.4 (31.4)

45.5 (25.6)

105.6 (29.0)

101.0 (33.1)

17.28 (<.001)

 Emotion recognition

.41 (.37)

.56 (.52)

.83 (.56)

.87 (.44)

1.85 (.48)

1.79 (.55)

14.45 (.001)

 Social avoidance

.19 (.31)

.27 (.42)

.35 (.45)

.45 (.51)

1.16 (.62)

1.08 (.65)

9.28 (.010)

 Interpersonal relationships

.23 (.39)

.38 (.55)

.57 (.67)

.72 (.71)

1.69 (.66)

1.59 (.71)

11.26 (.004)

 Repetitive sensory motor

.19 (.26)

.25 (.31)

.45 (.45)

.48 (.36)

1.35 (.60)

1.26 (.65)

18.11 (<.001)

 Insistence on sameness

.29 (.33)

.42 (.46)

.60 (.52)

.66 (.45)

1.63 (.51)

1.56 (.55)

16.75 (<.001)

DSM-5 SCI

 A1: socio-emotional reciprocity

.08 (.12)

.12 (.14)

.19 (.20)

.19 (.16)

.61 (.21)

.59 (.24)

14.20 (.001)

 A2: non-verbal communication

.15 (.14)

.16 (.15)

.27 (.19)

.29 (.16)

.64 (.19)

.61 (.21)

5.97 (.051)

 A3: relationships

.07 (.14)

.11 (.18)

.20 (.24)

.23 (.23)

.68 (.24)

.63 (.27)

11.80 (.003)

DSM-5 RRB

 B1: repetitive motor

.03 (.10)

.05 (.13)

.09 (.18)

.08 (.18)

.60 (.30)

.53 (.32)

21.74 (<.001)

 B2: resistance to change

.13 (.17)

.19 (.24)

.26 (.23)

.30 (.22)

.65 (.24)

.64 (.24)

9.43 (.009)

 B3: restricted interests

.06 (.14)

.11 (.16)

.17 (.22)

.17 (.19)

.66 (.25)

.62 (.27)

18.96 (<.001)

 B4: abnormal sensory

.05 (.11)

.08 (.13)

.15 (.21)

.12 (.16)

.53 (.25)

.49 (.27)

17.96 (<.001)

  1. Higher raw and T scores indicate higher levels of autism traits. Factor analytically derived SRS sub-scales are presented as raw item averages (range 0–3; 0 = not true, 1 = sometimes true, 2 = often true, 3 = almost always true). T scores are not currently available for these sub-scales. Each DSM-5 symptom score represents the proportion of endorsed items mapped to that symptom. Scale endpoints represent: 0 = no items endorsed by any individual and 1 = all items endorsed across all individuals