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Table 1 Sample characteristics of children with autism symptom questionnaire data from single and multiple incidence families in IAN

From: Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families

  Single incidence families Multiple incidence families Χ 2, t(p)
Number of families 2262 315  
 Female ASD-containing (N, %) 334 (14.8 %)a 125 (39.7 %)b Χ 2(1) = 117.3 (p < .001)
 Male-only (N, %) 1928 (85.2 %)a 190 (60.3 %)b  
Number of children 4764 751  
 ASD (N, %) 2262 (48.8 %)a 596 (80.6 %)b Χ 2(2) = 261.1 (p < .001)
 Non-ASD (N, %) 2097 (45.2 %)a 121 (16.4 %)b  
 Non-ASD with HLDAS 280 (6.0 %)a 22 (3.0 %)b
Age (M, SD, range) 8.7 (3.8, 4–18) 8.8 (3.6, 4–18) t(5513) = −0.6 (p = .522)
Female siblings (N, %) 1602 221  
 ASD (N, %) 333 (20.8 %)a 141 (63.8 %)b Χ 2(2) = 187.7 (p < .001)
 Non-ASD with HLDAS (N, %) 118 (7.4 %) 11 (5.0 %)  
 Non-ASD (N, %) 1151 (71.8 %)a 69 (31.2 %)b  
Race/ethnicity
 White non-Hispanic 4248 (89.2 %) 684 (91.1 %) Χ 2(1) = 2.5 (p = .114)
 Other or unknown 516 (10.8 %) 67 (8.9 %)  
SCQ total raw (M, SD) 12.4 (11.4) 17.5 (10.3) t(5513) = −11.54 (p < .001)
SRS total T score (M, SD) 64.7 (23.8) 77.1 (21.2) t(5513) = −13.47 (p < .001)
DSM-IV-TR (N, %)
 Autistic disorder 950 (42.0 %) 239 (40.1 %) Χ 2(2) = 10.7 (p = .005)
 PDD NOS 963 (42.6 %) 232 (38.9 %)
 Asperger’s disorder 349 (15.4 %)a 125 (21.0 %)b
  1. N = 137 non-ASD siblings could not be coded into HLDAS due to the missing data regarding the presence of language delay. The numbers of children in each category represent the number of children with complete symptom data and not the total number of children in the family. The numbers for DSM-IV-TR reflect only those with a specific DSM-IV-TR reported diagnosis. A small proportion of ASD-affected individuals did not have a specific DSM-IV-TR diagnosis reported (ASD or PDD was listed instead of a specific diagnosis). Lowercase letters a and b represent column proportions that are significantly different (Bonferroni adjusted p < .05). Age is presented as the child’s age when the SRS was completed