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Fig. 6 | Molecular Autism

Fig. 6

From: CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

Fig. 6

Overlap between DEGs from CHD8 +/− and previous knockdown studies of other ASD-risk genes. a Enrichment test for the overlaps between DEGs from CHD8 +/− NPCs and knockdowns of TCF4, EHMT1, MBD5, or SATB2, and between DEGs from CHD8 +/− neurons and knockdowns of ZNF804A or NRXN1. Bars represent p value (Fisher’s exact test, one-tailed), red dots represent odds ratio of overlap. b Network analysis of genes that were differentially expressed in NPCs in either CHD8 +/− or knockdown of at least two of the five genes (CHD8, TCF4, EHMT1, MBD5, and SATB2). The network was generated by STRING, with nodes representing genes and edges representing interactions. Size of the nodes is proportional to their connectivity. Colors of the nodes label the sources of DEGs. Two natural clusters are demarcated with ellipses. Disconnected genes were not shown

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Molecular Autism

ISSN: 2040-2392