Fig. 5
Enrichment of DEGs for ASD/schizophrenia-risk genes and genes associated with specific human phenotypes. a Enriched human phenotype from the Toppgene analysis for downregulated genes in neurons. p values were corrected by the Bonferroni method. b Enrichment of DEGs for ASD- and schizophrenia-risk genes. ASD-risk genes were collected from the SFARI database [54], AutismKB core dataset [55], and four other sets based on whole exome-sequencing and gene-expression network (Willsey_ASD [56], Liu_ASD [57], Iossifov_ASD [11] and DeRubeis_ASD [10]). The number of expressed genes in each set was in left parentheses. Schizophrenia-risk genes were obtained from either the SZGene database [58] or a recent GWAS report [59]. The red color in each cell corresponds to the −log10 (p value) for enrichment (Fisher’s exact test, one-tailed), as shown in the color scale on the right (shown only if p < 0.05). The first and the second number (in parenthesis) within each cell are the number of overlapping genes and the odds ratio of overlap, respectively