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Table 2 Gene-based SKAT-O results for genes in selected categories with p < 0.05

From: Targeted massively parallel sequencing of autism spectrum disorder-associated genes in a case control cohort reveals rare loss-of-function risk variants

Exonic (524 genes)

Nonsynonymous (499 genes)

Damaging (504 genes)

Gene

p values

Gene

p values

Gene

p values

CACNA2D1

0.000478745

PLA2G6

0.00959325

ERMAP

0.00955634

GNPTAB

0.004651201

CDC42EP4

0.010211946

SLC17A9

0.011358674

BICD1

0.008804534

SLC17A9

0.010656919

KIAA1274

0.01243212

PPM1H

0.011408084

AMIGO2

0.016812058

ZNF519

0.017563864

DDO

0.0124426

GNPTAB

0.018063006

ANKRD22

0.020850511

DGKG

0.015419571

OSGIN2

0.019535871

PA238

0.021527527

PKP4

0.0213883

ANKRD22

0.020850511

CDC42EP4

0.023737296

PARVA

0.022742454

PAX8

0.021527527

PTPRK

0.023809113

BACH2

0.026375169

ERMAP

0.021748476

PDK4

0.02412783

LOC158381

0.026815002

PDK4

0.024493537

OSGIN2

0.02476071

SLC17A9

0.032466663

SPON1

0.026942389

FMN2

0.026304563

IL17RA

0.035317441

NTRK3 a

0.027348276

SPON1

0.026942389

QBRICK

0.035922397

DGKI

0.030212727

SLITRK5

0.028283659

NRXN1 a

0.040563396

FAM19A4

0.030428212

DGKI

0.028626935

KCNH7

0.043770294

THAP2

0.042761309

SLC16A12

0.030211966

TG

0.047652525

C18orf22

0.044978318

FAM19A4

0.030428212

  

FGFR2

0.046420494

SLC24A2

0.031130372

  

SPANXN3

0.047977446

DDO

0.032382611

  

KCNH7

0.048279279

TG

0.035323522

    

KIAA0914

0.036561743

    

ZNF396

0.038298063

    

THAP2

0.046033231

    

C18orf22

0.046801921

    

PDZD2

0.046866496

    

LASS6

0.047604531

  1. Rare variants (MAF <0.01) within genes underwent gene-based association testing by SKAT-O. All genes with nominal SKAT-O p values <0.05 are represented
  2. aGene is a potential ASD candidate gene in the SFARI Gene Database (https://gene.sfari.org/autdb/)
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Molecular Autism

ISSN: 2040-2392