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Table 3 Significant differences in relative regional white matter volume between participants with ASD and TDC participants, after controlling for full-scale IQ

From: Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent

Tract-specific label Nearest gray matter region Hemisphere MNI coordinates T value Cluster-level P value a Cluster size (voxels)
   x y z
Model 1: ASD > TDC         
  Splenium of corpus callosum Precuneus L −18 −48 4 4.19 0.015 655
  Precuneus L −19 −46 21 3.57   
  Posterior cingulate gyrus L −16 −33 39 3.46   
  Splenium of corpus callosum Posterior cingulate gyrus R 21 −46 6 3.65 0.009 715
  Precuneus R 23 −46 24 3.46   
  Posterior cingulate gyrus R 18 −30 30 3.27   
Model 2: ASD > TDC         
  External capsule/anterior corona radiata Inferior orbitofrontal cortex R 23 20 −18 4.54 0.041 537
   R 26 32 −11 4.04   
   R 18 32 −18 3.64   
  Splenium of corpus callosum Precuneus L −18 −48 4 4.31 0.016 644
  Precuneus L −19 −46 21 3.61   
  Posterior cingulate gyrus L −16 −33 39 3.43   
  Splenium of corpus callosum Posterior cingulate gyrus R 21 −46 7 3.60 0.011 690
  Precuneus R 23 −46 24 3.42   
  Posterior cingulate gyrus R 18 −30 30 3.30   
Model 2: ASD by age > TDC by age         
  Forceps minor (anterior forceps) Anterior cingulate gyrus L −18 45 4 4.14 0.001 960
   L −25 20 −5 3.46   
   L −18 29 −2 3.33   
Model 3: Adolescent, ASD > TDC         
  Anterior corona radiata Anterior cingulate gyrus R 12 29 −9 4.10 0.001 1,151
   R 29 21 10 3.84   
   R 26 39 −5 3.74   
  1. ASD, autism spectrum disorder; TDC, typically developing control; L, left; R, right; MNI, Montreal Neurological Institute. aStatistical threshold was all set at FWE-corrected cluster-level P < 0.05, with cluster-forming voxel-level P < 0.005.