Figure 4

Manhattan plots of association study results. Results of association studies comparing 208 affected females and 151 unaffected females from AGRE. To maximize the ability to identify a candidate variant for the FPE the association test was performed on three tiers of SNPs, based on the a priori probability of mediating the FPE. (A) Tier 1: 451 SNPs unique to chromosome X that escape X-inactivation. No SNPs are significant after multiple comparisons (horizontal red line). The top five SNPs (red) are labeled (Table 1). (B) Tier 2: all 6,955 SNPs on chromosome X. No SNPs are significant after multiple comparisons (horizontal red line). The top five SNPs (red) are labeled (Table 2). (C) Tier 3: all 317,574 SNPs across the genome. No SNPs are significant after multiple comparisons (horizontal red line). The top five SNPs (red) are labeled (Table 3).