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Table 1 Ratio of affected males to females in multiplex families from AGRE

From: Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins

  Number of families Number of affected children Number of affected males Number of affected females Male:Female
All diagnosesa 1,120 2,404 1,867 537 3.48
Autism 1,106 2,158 1,700 458 3.71
Spectrumb 220 246 167 79 2.11
Top quartile (≥75) VABSc 319 445 312 133 2.35
Bottom quartile (≤50) VABSc 306 424 340 84 4.05
  1. aAll diagnoses = autism, broad-spectrum, or not quite autism (NQA) study diagnoses; bSpectrum = broad-spectrum or NQA; cVABS quartiles calculated from composite standard scores for affected children from AGRE multiplex families. VABS, Vineland Adaptive Behavior Scales.