Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins

Table 1 Ratio of affected males to females in multiplex families from AGRE

	Number of families	Number of affected children	Number of affected males	Number of affected females	Male:Female
All diagnoses^a	1,120	2,404	1,867	537	3.48
Autism	1,106	2,158	1,700	458	3.71
Spectrum^b	220	246	167	79	2.11
Top quartile (≥75) VABS^c	319	445	312	133	2.35
Bottom quartile (≤50) VABS^c	306	424	340	84	4.05

^aAll diagnoses = autism, broad-spectrum, or not quite autism (NQA) study diagnoses; ^bSpectrum = broad-spectrum or NQA; ^cVABS quartiles calculated from composite standard scores for affected children from AGRE multiplex families. VABS, Vineland Adaptive Behavior Scales.

ISSN: 2040-2392