Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome

Table 1 Fractional anisotropy (FA) values in individuals with Asperger syndrome (AS) and controls in the white matter (WM) tracts reconstructed with tractography

WM ^a tract	FA ^a (AS ^a subjects) ^b	FA ^a (controls) ^b	Pvalue ^c	Corrected Pvalue ^c
ATR ^a L	0.3416 ± 0.0381	0.3335 ± 0.0330	0.2629	3.418
ATR ^a R	0.3511 ± 0.0399	0.3453 ± 0.0332	0.3330	4.329
SCC ^a	0.4521 ± 0.0225	0.4401 ± 0.0553	0.1995	2.593
CST ^a L	0.4957 ± 0.0254	0.4848 ± 0.0405	0.1757	2.284
CST ^a R	0.4915 ± 0.0278	0.4713 ± 0.0420	0.05339	0.6941
IFO ^a L	0.4381 ± 0.0336	0.4129 ± 0.0523	0.05162	0.6710
IFO ^a R	0.4365 ± 0.0261	0.4112 ± 0.0342	0.01095	0.1423
ILF ^a L	0.3864 ± 0.0277	0.3521 ± 0.0358	0.002026	0.02633
ILF ^a R	0.3697 ± 0.0258	0.3511 ± 0.0380	0.05233	0.6803
SLF ^a L	0.4266 ± 0.0154	0.3978 ± 0.0433	0.006523	0.08480
SLF ^a R	0.3899 ± 0.0255	0.3620 ± 0.0434	0.01405	0.1826
UNC ^a L	0.3426 ± 0.0368	0.3109 ± 0.0424	0.01470	0.1911
UNC ^a R	0.3353 ± 0.0373	0.3143 ± 0.0408	0.06743	0.8766

^aFA, fractional anisotropy; AS, Asperger syndrome; WM, white matter; ATR, anterior thalamic radiation; SCC, splenium of corpus callosum; CST, corticospinal tract; IFO, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UNC, uncinate fasciculus.
^bMean and standard deviations are presented for both groups.
^cBoth uncorrected and Bonferroni-corrected P values from two-sample t-tests are presented. A significant P value (corrected P <0.05) is highlighted in bold.

ISSN: 2040-2392