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Table 2 SRM-MS testing of targeted candidate proteins in post mortem prefrontal cortex and cerebellum from autism patients compared to matched controls

From: Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

    Prefrontal cortex Cerebellum     Prefrontal cortex
Pathways Gene Protein name ratio P-value Pathways Gene Protein name ratio
Cell adhesion RELN Reelin ND ND Cell adhesion RELN Reelin ND
Astrocyte GFAP Glial fibrillary acidic protein 1.02 0.7399 0.7968 1.14 1.8E-05a 7.42E-5
VIME Vimentin 0.69 2.8E-5a 0.0002 0.56 1 < E-10a 1 < E-9
Energy CKB Creatine kinase B-type 1.73 1.3E-9a 1.82E-8 0.92 0.2605 0.3777
Myelin MAG Myelin-associated glycoprotein 0.76 0.0087a 0.0272 1.30 0.0016a 0.0042
MBP Myelin basic protein 0.85 0.1440 0.2373 1.41 0.0003a 0.0009
MOG Myelin-oligodendrocyte glycoprotein 0.81 0.0567 0.1222 1.37 0.0002a 0.0006
PLP1 Myelin proteolipid protein 0.82 0.0143a 0.0400 1.37 2.8E-10a 2.69E-9
Synaptic vesicle DNM2 Dynamin-2 1.05 0.7811 0.8024 0.87 0.2910 0.4018
STX1A Syntaxin-1A 1.07 0.2086 0.3165 0.88 0.0102a 0.0227
STXBP1 Syntaxin-binding protein 1 1.28 0.1002 0.1753 0.97 0.8031 0.8626
SYN2 Synapsin-2 1.29 0.0486a 0.1135 1.04 0.6499 0.7539
SYT1 Synaptotagmin-1 1.06 0.4092 0.5456 0.87 0.0165a 0.0342
PACSIN1 Protein kinase C casein kinase substrate 1 0.96 0.4540 0.5778 0.84 8.1E-5a 0.0003
  1. ND = not detected; asignificant P-value.
  2. Indicated are the themes, protein name, the ratio (autism/control), the P-value and the Q-value. Grey shading indicates the proteins with a significant P-value or Q-value and a ratio of >10%.