Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome

Table 4 Summary of significant sex-diagnosis interactions of serum molecules measured by LC-MS ^E profiling

				Males		Females
Code	Protein	Interaction	FDR	Ratio	P-value	Ratio	P-value
RGPD4	RANBP2-like and GRIP domain containing 5	0.015	0.723	0.89	0.016	1.07	0.893
ARMC3	Armadillo repeat containing 3	0.002	0.291	0.88	0.183	1.29	0.001
PTPA	PP 2A activator, reg subunit 4	0.038	0.723	0.97	0.681	1.23	0.001
TLE1	Transducin-like enhancer of split 1	0.049	0.723	0.90	0.394	1.22	0.026
CLC4K	CD207 molecule, langerin	0.017	0.723	0.96	0.720	1.20	<0.001
GLCE	Glucuronic acid epimerase	0.017	0.723	0.88	0.231	1.19	0.018
APOC2	Apolipoprotein C2	0.005	0.522	0.92	0.254	1.19	0.001
ZC3HE	Zinc finger CCCH-type containing 14	0.039	0.723	0.97	0.383	1.16	0.020
FETUB	Fetuin B	0.035	0.723	0.96	0.572	1.15	0.004
RN149	Ring finger protein 149	0.044	0.723	1.02	0.588	1.14	0.042
TRIPB	Thyroid hormone receptor interactor 11	0.012	0.723	0.94	0.610	1.13	0.027
APOE	Apolipoprotein E	0.030	0.723	0.99	0.851	1.11	<0.001
MRRP1	RNA G9 methyltransferase domain cont 1	0.044	0.723	1.06	0.592	0.78	0.035

Indicated are the P-values and FDR (false discovery rate) of the interactions and the separate ratio (AS/control; calculated using geometric means) changes with P-values in males in females. Values in bold font indicate significant differences between AS and typical individuals by sex.