Table 1 Analysis of protein levels in serum of NR1 neo−/− (n = 12) and wildtype mice (n = 12) using multiplexed immunoassay
A) | ||||||
|---|---|---|---|---|---|---|
Protein Name | UniProt ID | Gene name | Ratio NR1/Wt | P | P* | |
C-C motif chemokine 12 | Q62401 | Ccl12 | â–¼ | 0.52 | 0.0002 | 0.0060 |
Insulin-like growth factor I (IGF-I) | P05017 | Igf1 | â–¼ | 0.16 | 0.0002 | 0.0060 |
Osteopontin (2AR) | P10923 | Spp1 | â–¼ | 0.36 | 0.0003 | 0.0060 |
Interleukin-12 subunit alpha (IL-12A) | P43431 | IL12A | â–² | 1.86 | 0.0004 | 0.0060 |
Vascular endothelial growth factor A (VEGFA) – assay 1 | Q00731 | Vegfa | ▲ | 7.41 | 0.0004 | 0.0060 |
– assay 2 | ▲ | 8.26 | 0.0006 | 0.0061 | ||
von Willebrand factor (vWF) | Q8CIZ8 | Vwf | â–² | 2.98 | 0.0005 | 0.0061 |
Fibrinogen, alpha polypeptide (Protein Fga) | Q99K47 | Fga | â–² | 13.19 | 0.0007 | 0.0061 |
Apolipoprotein A-I (ApoA1) | Q00623 | Apoa1 | â–² | 16.77 | 0.0007 | 0.0061 |
C-X-C motif chemokine 5 (Cytokine LIX) | P50228 | Cxcl5 | â–¼ | 0.75 | 0.0023 | 0.0143 |
Eotaxin (C-C motif chemokine 11) | P48298 | Ccl11 | â–¼ | 0.50 | 0.0024 | 0.0143 |
Lymphotactin (C motif chemokine 1) | P47993 | Xcl1 | â–¼ | 0.56 | 0.0025 | 0.0143 |
Clusterin (Apolipoprotein J) | Q06890 | Clu | â–¼ | 0.61 | 0.0028 | 0.0152 |
Macrophage colony-stimulating factor 1 (CSF-1) | P07141 | Csf1 | â–² | 1.65 | 0.0031 | 0.0156 |
Immunoglobulin A (IgA) | NA | NA | â–¼ | 0.75 | 0.0035 | 0.0158 |
Glutathione S-transferase Mu 1 | P10649 | Gstm1 | â–² | 1.57 | 0.0036 | 0.0158 |
Leptin (Obesity factor) | P41160 | Lep | â–¼ | 0.49 | 0.0051 | 0.0206 |
C-C motif chemokine 7 (MCP-3) | Q03366 | Ccl7 | â–¼ | 0.51 | 0.0052 | 0.0206 |
Interleukin-1 beta (IL-1 beta) | P10749 | IL1B | â–¼ | 0.58 | 0.0103 | 0.0358 |
Adrenocorticotropic hormone (ACTH) | P01193 | Pomc | â–¼ | 0.58 | 0.0105 | 0.0358 |
Oncostatin-M (OSM) | P53347 | Osm | â–² | 2.15 | 0.0114 | 0.0370 |
Glucagon | P55095 | Gcg | â–² | 1.42 | 0.0202 | 0.0612 |
CC chemokine DC/B-CK (Chemokine (C-C motif) ligand 22) | Q546S6 | Ccl22 | â–¼ | 0.82 | 0.0210 | 0.0612 |
Interleukin-11 (IL-11) | P47873 | Il11 | â–² | 1.52 | 0.0212 | 0.0612 |
Epidermal growth factor (EGF) – assay 1 | P07522 | Egf | ▲ | 2.42 | 0.0235 | 0.0654 |
– assay 2 | ▲ | 2.12 | 0.0287 | 0.0718 | ||
Myeloperoxidase (MPO) | P11247 | Mpo | â–² | 1.53 | 0.0246 | 0.0659 |
Tumor necrosis factor (TNF-alpha) | P06804 | Tnf | â–² | 1.66 | 0.0283 | 0.0718 |
Coagulation factor VII | P70375 | F7 | â–¼ | 0.86 | 0.0309 | 0.0748 |
Neutrophil gelatinase-associated lipocalin (NGAL) | P11672 | Lcn2 | â–² | 3.27 | 0.0443 | 0.1038 |
Endothelin-1 (ET-1) | P22387 | Edn1 | â–¼ | 0.72 | 0.0473 | 0.1075 |