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Table 1 Analysis of protein levels in serum of NR1 neo−/− (n = 12) and wildtype mice (n = 12) using multiplexed immunoassay

From: Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders

A)      
Protein Name UniProt ID Gene name Ratio NR1/Wt P P*
C-C motif chemokine 12 Q62401 Ccl12 0.52 0.0002 0.0060
Insulin-like growth factor I (IGF-I) P05017 Igf1 0.16 0.0002 0.0060
Osteopontin (2AR) P10923 Spp1 0.36 0.0003 0.0060
Interleukin-12 subunit alpha (IL-12A) P43431 IL12A 1.86 0.0004 0.0060
Vascular endothelial growth factor A (VEGFA) – assay 1 Q00731 Vegfa 7.41 0.0004 0.0060
– assay 2    8.26 0.0006 0.0061
von Willebrand factor (vWF) Q8CIZ8 Vwf 2.98 0.0005 0.0061
Fibrinogen, alpha polypeptide (Protein Fga) Q99K47 Fga 13.19 0.0007 0.0061
Apolipoprotein A-I (ApoA1) Q00623 Apoa1 16.77 0.0007 0.0061
C-X-C motif chemokine 5 (Cytokine LIX) P50228 Cxcl5 0.75 0.0023 0.0143
Eotaxin (C-C motif chemokine 11) P48298 Ccl11 0.50 0.0024 0.0143
Lymphotactin (C motif chemokine 1) P47993 Xcl1 0.56 0.0025 0.0143
Clusterin (Apolipoprotein J) Q06890 Clu 0.61 0.0028 0.0152
Macrophage colony-stimulating factor 1 (CSF-1) P07141 Csf1 1.65 0.0031 0.0156
Immunoglobulin A (IgA) NA NA 0.75 0.0035 0.0158
Glutathione S-transferase Mu 1 P10649 Gstm1 1.57 0.0036 0.0158
Leptin (Obesity factor) P41160 Lep 0.49 0.0051 0.0206
C-C motif chemokine 7 (MCP-3) Q03366 Ccl7 0.51 0.0052 0.0206
Interleukin-1 beta (IL-1 beta) P10749 IL1B 0.58 0.0103 0.0358
Adrenocorticotropic hormone (ACTH) P01193 Pomc 0.58 0.0105 0.0358
Oncostatin-M (OSM) P53347 Osm 2.15 0.0114 0.0370
Glucagon P55095 Gcg 1.42 0.0202 0.0612
CC chemokine DC/B-CK (Chemokine (C-C motif) ligand 22) Q546S6 Ccl22 0.82 0.0210 0.0612
Interleukin-11 (IL-11) P47873 Il11 1.52 0.0212 0.0612
Epidermal growth factor (EGF) – assay 1 P07522 Egf 2.42 0.0235 0.0654
– assay 2 2.12 0.0287 0.0718
Myeloperoxidase (MPO) P11247 Mpo 1.53 0.0246 0.0659
Tumor necrosis factor (TNF-alpha) P06804 Tnf 1.66 0.0283 0.0718
Coagulation factor VII P70375 F7 0.86 0.0309 0.0748
Neutrophil gelatinase-associated lipocalin (NGAL) P11672 Lcn2 3.27 0.0443 0.1038
Endothelin-1 (ET-1) P22387 Edn1 0.72 0.0473 0.1075
  1. The table includes Uniprot ID, gene names, ratios (calculated based on average), P values (Mann-Whitney U-test), and adjusted P values (P*, Benjamini-Hochberg corrected). Significant analytes with an increase/decrease greater than 5-fold are highlighted in bold.
  2. downregulated, ▲ upregulated.