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Figure 8 | Molecular Autism

Figure 8

From: N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism

Figure 8

SLC6A4 and NSF expression in lymphocytes. Comparison of SLC6A4 (A) and NSF (B) expression levels in lymphocytes from control and ASD subjects. The Mann–Whitney U test was used to compare gene expression levels between autism and control groups. Data are presented as the means ± standard error of the mean. n = 30 control and n = 30 autism. The NSF expression levels in ASD patients were significantly lower than in controls (P = 0.0011). (C) Correlation between lymphocyte NSF expression levels and Autism Diagnostic Interview-Revised (ADI-R) domain A scores in autistic subjects. There was a negative correlation between lymphocyte NSF expression levels and ADI-R domain A scores (r s = 0.131, P = 0.0498), n = 30 autism. ADI-R, autism diagnostic interview-revised; NSF, N-ethylmaleimide-sensitive factor.

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