Table 2 Levels of free and sulphated steroids in whole adult 40,XY and 39,X ^Y* O mouse brain (n = 4 per group)

Androsterone (5α-androstan-3α-ol-17-one)

ND; < 4.56

ND; < 4.56

N/A

ND; < 0.63

ND; < 0.63

N/A

dehydroepiandrosterone (5-androsten-3β-ol-17-one)

36.15 ± 9.74

32.91 ± 15.21

0.18, P = 0.86

0.51 ± 0.02

0.53 ± 0.01

−1.34, P = 0.23

Epiandrosterone (5α-androstan-3β-ol-17-one)

2.80 ± 0.12

3.60 ± 0.44

−1.77, P = 0.13

0.71 ± 0.02

0.72 ± 0.01

−0.66, P = 0.54

Androstenediol (5-androsten-3β,17β-diol)

ND; < 0.01

ND; < 0.01

N/A

ND; < 0.45

ND; < 0.45

N/A

17β-oestradiol(1,3,5(10)-oestratrien-3,17β-diol)

ND; < 0.53

ND; < 0.53

N/A

ND; < 0.05

ND; < 0.05

N/A

Testosterone (4-androsten-17β-ol-3-one)

19.64 ± 2.27

19.63 ± 9.81

0.00, P = 1.00

ND; < 1.77

ND; < 1.77

N/A

Allopregnanolone (5α-pregnan-3α-ol-20-one)

1.47 ± 0.27

1.95 ± 0.77

−0.59, P = 0.58

ND; < 0.01

ND; < 0.01

N/A

Allopregnanediol (5α-pregnan-3α,20α-diol)

ND; < 0.01

ND; < 0.01

N/A

ND; < 0.01

ND; < 0.01

N/A

Pregnenolone (5-pregnen-3β-ol-20-one)

31.26 ± 13.37

25.12 ± 15.05

0.31, P = 0.77

ND; < 0.01

ND; < 0.01

N/A

Epiallopregnanolone (5α-pregnan-3β-ol-20-one)

17.07 ± 5.13

25.25 ± 17.19

−0.46, P = 0.67

ND; < 0.37

ND; < 0.37

N/A

5α-dihydroprogesterone (5α-pregnan-3,20-dione)

12.75 ± 5.26

15.01 ± 6.16

−0.28, P = 0.79

ND; < 0.01

ND; < 0.01

N/A

20β-dihydropregnenolone (5-pregnen-3β,20β-diol)

ND; < 3.10

ND; < 3.10

N/A

ND; < 0.01

ND; < 0.01

N/A

20α-dihydropregnenolone (5-pregnen-3β,20α-diol)

0.91 ± 0.11

0.94 ± 0.09

−0.21, P = 0.84

ND; < 0.01

ND; < 0.01

N/A

Progesterone (4-pregnen-3,20-dione)

3.74 ± 0.34

5.84 ± 2.05

−1.01, P = 0.35

ND; < 4.41

ND; < 4.41

N/A

5α,20α-tetrahydroprogesterone (5α-pregnan-20α-ol-3-one)

3.71 ± 0.22

3.97 ± 0.48

−0.50, P = 0.64

ND; < 1.61

ND; < 1.61

N/A