Figure 5

Significant sex-differential linkage peaks. Regions of sex subgroup-specific suggestive linkage (logarithm of odds (LOD) ≥2.2) with empirically significant signal enrichment from randomization testing are plotted. (A) 1p31.3, MO; top: linkage across full chromosome 1 from all stage 1 family groups; upper-middle: linkage from all stage 1 (solid lines) and combined sample (dashed lines) family groups and association signal from transmission disequilibrium test (TDT; black dots, EMP1 is empirical P-value from TDT) in male-only (MO) families across 2-LOD interval from peak LOD; lower-middle: empirical P-values from test of linkage subgroup specificity (black = stage 1, gray = combined), dotted lines indicate thresholds corresponding to empirical P-values of 0.05, 0.01, and 0.005; bottom: RefSeq gene alignment in 2-LOD interval. (B) Linkage across full chromosome 8 from all stage 1 family groups. (C) 8p21.2, female-containing (FC), (D) 8p12, FC; for each, top: linkage from all stage 1 family groups and TDT association in FC families across 2-LOD interval from peak LOD; middle: empirical P-values from stratification permutation tests; bottom, RefSeq gene alignment in 2-LOD interval.