Flowchart of sequencing and filtering methods to identify and prioritize IBD variants. The data from whole exome sequencing as well as two genotyping platforms, whole genome SNP array and exome chip array, were each independently generated and processed. SNP array genotyping calls were compared to variants identified by exome sequencing as a quality check. Independent confirmation of calls from exome sequencing were made either by genotyping on the HumanExome BeadChip or by traditional Sanger sequencing. IBD, identical by descent.