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Table 1 Enrichment of autism spectrum disorder (ASD)-related genes in En2 -/- cerebellum and hippocampus differentially expressed genes

From: Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders

(a) Cerebellum
Gene Symbol Gene Name P value Fold change
Ada adenosine deaminase 3.50E-03 1.705
Ahi1 Abelson helper integration site 1 4.70E-03 1.690
Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 8.20E-03 0.670
Cdh10 cadherin 10 4.40E-03 1.662
Eml1 echinoderm microtubule associated protein like 1 2.80E-03 0.581
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 9.90E-03 0.653
Glo1 glyoxalase 1 6.00E-03 0.625
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 5.60E-03 1.565
Grm5 glutamate receptor, metabotropic 5 3.70E-03 1.656
Itgb7 integrin beta 7 1.00E-04 0.453
Kdm5c lysine (K)-specific demethylase 5C 8.50E-03 0.660
Kit kit oncogene 3.00E-03 0.591
Nrp2 neuropilin 2 0.00 2.503
Nrxn3 neurexin III 1.80E-03 1.843
Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin 5.20E-03 1.723
Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 1.00E-03 1.871
Plcb1 phospholipase C, beta 1 3.60E-03 1.677
Rb1cc1 RB1-inducible coiled-coil 1 6.90E-03 1.635
Rpp25 ribonuclease P 25 subunit (human) 8.00E-03 0.619
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 9.40E-03 1.548
Th tyrosine hydroxylase 7.90E-03 1.564
(b) Hippocampus
Gene Symbol Gene Name P value Fold change
Aff4 AF4/FMR2 family, member 4 1.30E-03 4.490
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 2.80E-03 0.544
Baiap2 brain-specific angiogenesis inhibitor 1-associated protein 2 8.00E-04 0.478
Camta1 calmodulin binding transcription activator 1 4.40E-03 0.561
Dab1 disabled homolog 1 (Drosophila) 4.10E-03 0.552
Dctn5 dynactin 5 4.10E-03 1.733
Dlg4 discs, large homolog 4 (Drosophila) 0.00 0.346
Egr2 early growth response 2 7.00E-04 2.099
Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 3.90E-03 0.551
Ep400 E1A binding protein p400 2.00E-04 2.361
Foxp1 forkhead box P1 3.00E-04 0.425
Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 4.00E-04 2.151
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 3.90E-03 0.555
Gsk3b glycogen synthase kinase 3 beta 3.50E-03 0.541
Gtf2i general transcription factor II I 3.80E-03 0.552
Kit kit oncogene 2.00E-04 0.417
Klc2 kinesin light chain 2 4.80E-03 0.565
Lrrc1 leucine rich repeat containing 1 4.20E-03 1.742
Nrcam neuron-glia-CAM-related cell adhesion molecule 3.10E-03 1.777
Ntng1 netrin G1 1.90E-03 1.842
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 1.00E-04 0.426
Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin 1.00E-04 2.402
Plcb1 phospholipase C, beta 1 8.00E-04 0.487
Prkcb protein kinase C, beta 8.00E-04 0.490
Rpp25 ribonuclease P 25 subunit (human) 1.10E-03 0.487
Sbf1 SET binding factor 1 4.40E-03 0.562
Scn1a sodium channel, voltage-gated, type I, alpha 1.00E-04 0.410
Scn8a sodium channel, voltage-gated, type VIII, alpha 1.00E-04 0.414
Syn1 synapsin I 5.00E-04 0.469
Syne1 synaptic nuclear envelope 1 4.80E-03 0.562
Thra thyroid hormone receptor alpha 1.00E-04 0.419
Ube2h ubiquitin-conjugating enzyme E2H 4.00E-03 0.559
Ubl7 ubiquitin-like 7 (bone marrow stromal cell-derived) 3.70E-03 0.557
  1. ASD-related genes enriched in the En2-/- (a) cerebellum and (b) hippocampus with their differential expression P value and fold change.