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Table 2 Autistic impairments and neurobehavioral characteristics

From: Presence of autism, hyperserotonemia, and severe expressive language impairment in Williams-Beuren syndrome

Characteristics

Patient 1

Patient 2

Autistic behavioral domains and autism diagnosisa

  

ADI–R

  

 Abnormalities of development evident at or before age 36 months (cutoff = 1)

5

4

 Nonverbal communication (cutoff = 7)

14

12

 Reciprocal social interaction (cutoff = 10)

26

23

 Repetitive behaviors and stereotyped patterns (cutoff = 3)

9

9

ADOS (module 1)

  

 Communication (cutoff = 4)

5

5

 Reciprocal social interaction (cutoff = 7)

13

8

 Communication + social interaction total (cutoff = 12)

18

13

 Play

3

1

 Repetitive behaviors and stereotyped patterns

5

4

Expressive behaviors

  

 Verbal language

None (total absence of words)

None (total absence of words)

 Self-injurious behaviors

Ear-slapping, hand-biting

Self-scratching until bleeding, elbow-banging

  1. aAccording to the ADI–R (parental interview) or the ADOS (direct observation of the patient) algorithm, the DSM-IV-TR and the ICD-10 diagnostic criteria for autistic disorder are fulfilled when the total scores of each domain reach the cutoff point.