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Table 2 Top five biological functions, disorders, and canonical pathways associated with 2,544 potential transcriptional targets of RORA

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Biological functions, disorders, and pathways P value Number of molecules
Physiological system development and function   
Organismal survival 3.56E-08 to 6.82E-04 305
Nervous system development and function 5.83E-08 to 4.28E-03 344
Tissue morphology 5.83E-08 to 4.72E-03 419
Cardiovascular system development and function 8.89E-08 to 4.72E-03 268
Embryonic development 9.01E-08 to 4.72E-03 370
Diseases and disorders   
Hereditary disorder 8.09E-06 to 1.56E-03 204
Neurological disease 8.09E-06 to 4.72E-03 292
Psychological disorders 8.09E-06 to 8.09E-06 107
Cancer 1.65E-05 to 4.77E-03 731
Hematological disease 1.65E-05 to 4.67E-03 166
Top canonical pathways   Ratio
Superpathway of inositol phosphate compounds 4.97E-04 37/227
Production of nitric oxide and reactive oxygen species in macrophages 1.29E-03 35/210
Axonal guidance signaling 2.47E-03 69/468
3-phosphoinositide biosynthesis 2.52E-03 29/175
Small cell lung cancer signaling 2.60E-03 17/89
  1. These data were obtained using Ingenuity Pathway Analysis software. P values were calculated using Fisher's exact test, which was performed using the entire set of genes within the Ingenuity Knowledge Base as the reference set.