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Table 8 QFAM analyses for family-based association tests for quantitative RRB traits and SLC25A12 SNPs in the SSC sample (n = 720 trio families)

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

  rs2056202 (na = 720) rs908670 (n = 718) rs2292813 (n = 720)
Risk allele (frequency) A (0.152) G (0.281) A (0.107)
Stereotyped behavior    
βb 0.208 -0.140 0.087
EMP1c 0.004 0.014 0.309
Permutation p 0.004 d 0.014 d 0.316
Self-injurious behavior    
βb 0.186 -0.171 0.029
EMP1c 0.010 0.003 0.738
Permutation p 0.016 d 0.001 d 0.742
Compulsive behavior    
βb 0.131 -0.095 0.012
EMP1c 0.070 0.098 0.885
Permutation p 0.072 e 0.083 e 0.883
Ritualistic behavior    
βb 0.141 -0.036 0.063
EMP1c 0.049 0.532 0.461
Permutation p 0.053 e 0.534 0.471
Sameness behavior    
βb 0.197 -0.064 0.154
EMP1c 0.006 0.265 0.073
Permutation p 0.008 d 0.270 0.078 e
Restricted behavior    
βb 0.233 -0.078 0.200
EMP1c 0.001 0.172 0.019
Permutation p 0.001 d 0.162 0.020 d
Sum    
βb 0.211 -0.115 0.105
EMP1c 0.004 0.046 0.224
Permutation p 0.005 d 0.047 d 0.220
  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cUncorrected single-point P value.
  4. Permutation p value: dp < 0.05; ep < 0.1.