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Table 6 Haplotype analyses for association between quantitative RRB traits and rs2056202-rs908670-rs2292813 haplotype

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

  UIC-UF sample (n = 179 probands) SSC sample (n = 720 probands)
Haplotype (frequency) ATA (0.162) GCG (0.299) ATG (0.056) GTG (0.483) Omnibus ATA (0.107) GCG (0.281) ATG (0.045) GTG (0.568) Omnibus
Stereotyped behavior           
βb 0.261 0.126 -0.061 -0.212 N/A 0.171 -0.441 1.300 0.064 N/A
Statc 3.150 1.160 0.075 4.300 5.470 0.394 6.010 11.700 0.154 16.100
EMP1d 0.078 0.271 0.782 0.036 0.138 0.524 0.013 0.001 0.700 0.001
Permutation p 0.236 0.656 0.991 0.130 0.138 0.907 0.049 d 0.003 d 0.972 0.001 d
Self-injurious behavior           
βb 0.276 -0.069 -0.102 -0.058 N/A 0.028 -0.464 1.190 0.151 N/A
Statc 3.260 0.327 0.201 0.285 3.290 0.014 8.730 13.000 1.120 19.600
EMP1d 0.076 0.561 0.649 0.596 0.351 0.907 0.005 0.001 0.289 0.001
Permutation p 0.228 0.927 0.964 0.941 0.351 0.999 0.015 d 0.002 d 0.665 0.001 d
Compulsive behavior           
βb 0.138 0.200 -0.222 -0.175 N/A 0.016 -0.352 1.230 0.058 N/A
Statc 0.811 2.760 0.963 2.700 4.640 0.002 2.640 7.220 0.087 8.940
EMP1d 0.362 0.099 0.328 0.103 0.202 0.959 0.099 0.007 0.765 0.030
Permutation p 0.772 0.300 0.726 0.310 0.202 1.000 0.307 0.026 d 0.989 0.030 d
Ritualistic behavior           
βb 0.414 -0.095 -0.096 -0.105 N/A 0.167 -0.114 0.936 -0.139 N/A
Statc 7.620 0.627 0.181 0.974 7.590 0.252 0.269 4.110 0.489 4.560
EMP1d 0.006 0.427 0.675 0.324 0.054 0.619 0.599 0.046 0.489 0.211
Permutation p 0.024 d 0.836 0.969 0.719 0.054 e 0.952 0.947 0.142 0.879 0.211
Sameness behavior           
βb 0.420 -0.080 -0.156 -0.105 N/A 0.945 -0.378 1.350 -0.280 N/A
Statc 7.600 0.436 0.468 0.942 7.570 3.310 1.200 3.490 0.810 7.630
EMP1d 0.007 0.513 0.502 0.336 0.060 0.071 0.263 0.059 0.368 0.056
Permutation p 0.027 d 0.899 0.890 0.736 0.060 e 0.212 0.645 0.192 0.769 0.056 e
Restricted behavior           
βb 0.279 -0.046 -0.383 -0.015 N/A 0.454 -0.186 0.624 -0.125 N/A
Statc 3.380 0.143 2.920 0.019 5.430 3.810 1.460 3.700 0.801 8.470
EMP1d 0.066 0.705 0.085 0.893 0.147 0.051 0.225 0.055 0.368 0.038
Permutation p 0.213 0.977 0.270 0.999 0.147 0.164 0.563 0.176 0.770 0.038 d
Sum           
βb 0.389 -0.045 -0.171 -0.118 N/A 1.450 -1.890 5.960 -0.046 N/A
Statc 6.490 0.137 0.543 1.170 6.520 0.955 3.700 8.150 0.003 11.500
EMP1d 0.012 0.706 0.457 0.276 0.094 0.329 0.056 0.006 0.959 0.009
Permutation p 0.044 d 0.981 0.861 0.656 0.094 e 0.723 0.175 0.019 d 1.000 0.009 d
  1. aStandardized regression coefficient (negative value indicates negative correlation).
  2. bWald test was used to compare tested haplotype with the remaining haplotypes.
  3. cUncorrected single-point P value.
  4. Permutation p value: dp < 0.05; ep < 0.1. N/A: not applicable.