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Table 4 Linear regression analyses for association between quantitative RRB traits and SLC25A12 SNPs after controlling for age, gender, population and FSIQ in the SSC sample

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

Sample SSC sample (n = 720 probands)
SNP rs2056202 (na = 714) rs908670 (n = 712) rs2292813 (n = 714)
Risk allele (frequency) A (0.151) G (0.291) A (0.102)
Stereotyped behavior    
βb 0.655 -0.444 0.211
Statc 2.883 -2.499 0.783
EMP1d 0.005 0.012 0.441
Permutation p 0.012 e 0.033 e 0.763
Self-injurious behavior    
βb 0.484 -0.468 0.044
Statc 2.408 -2.990 0.183
EMP1d 0.016 0.003 0.857
Permutation p 0.044 e 0.008 e 0.995
Compulsive behavior    
βb 0.531 -0.356 0.055
Statc 1.915 -1.651 0.169
EMP1d 0.057 0.096 0.872
Permutation P 0.132 0.230 0.996
Ritualistic behavior    
βb 0.491 -0.114 0.183
Statc 1.749 -0.519 0.551
EMP1d 0.077 0.606 0.573
Permutation p 0.186 0.904 0.889
Sameness behavior    
βb 1.222 -0.377 0.975
Statc 2.797 -1.095 1.880
EMP1d 0.005 0.280 0.061
Permutation p 0.014 e 0.548 0.151
Restricted behavior    
βb 0.579 -0.188 0.469
Statc 2.953 -1.223 2.019
EMP1d 0.003 0.220 0.042
Permutation p 0.008 e 0.462 0.107
Sum    
βb 3.485 -1.889 1.615
Statc 2.784 -1.937 1.096
EMP1d 0.005 0.057 0.276
Permutation p 0.015 e 0.135 0.546
  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cCoefficient t-statistics.
  4. dUncorrected single-point p value.
  5. Permutation p value: eP< 0.05.