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Table 2 Results of histopathological changes in BTBR versus B6 mice

From: Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

Marker PFC STR ACC AMG HPC Comments
AchE 0 0 0 0 0  
BrdU N/A N/A N/A N/A -  
   + GFAP N/A N/A N/A N/A +  
   + NeuN N/A N/A N/A N/A -  
CNPase 0 0 + 0 0 Focal in CC region
Drebrin 0 0 - 0 0  
Doublecortin 0 0 0 0 -  
GAD65 0 0 - 0 0  
GAD67 0 0 - 0 0  
GFAP 0 0 0 0 0 Misorientation (alv., cing.)
GluR1 0 0 - 0 0  
Iba1 0 0 0 0 0 Misorientation (alv., cing.)
MAP2 0 0 0 0 0  
MBP 0 0 + 0 0 Focal in CC region
NeuroD N/A N/A N/A N/A -  
NG2 0 0 ++ 0 0  
Parvalbumin 0 0 - 0 0  
PSA-NCAM 0 0 0 0 -  
PSD-95 0 0 - 0 0  
Synapsin 2 0 0 - 0 0  
Synaptophysin 0 0 - 0 0  
Timm's 0 0 0 0 0  
VGluT1 0 0 - 0 0  
  1. PFC = prefrontal cortex; STR = striatum; ACC = anterior cingulate cortex; AMG = amygdala; HPC = hippocampus; AchE = acetylcholinesterase; BrdU = 5-bromo-2'-deoxyuridine; CNPase = 2',3'-cyclic nucleotide 3'-phosphodiesterase; GAD65 = glutamic acid decarboxylase 65 kDa isoform; GAD67 = glutamic acid decarboxylase 67 kDa isoform; GFAP = glial fibrillary acidic protein; GluR1 = glutamate receptor 1; Iba1 = ionized calcium-binding adaptor molecule 1; MAP2 = microtubule-associated protein 2; MBP = myelin basic protein; N/A: not analyzed; NeuN = neuronal nuclei; PSA-NCAM = poly-sialic acid neural cell adhesion molecule; PSD-95 = postsynaptic density protein of 95 kDa; VGluT1 = vesicular glutamate transporter 1.
  2. Comments refer to alterations probably related to callosal agenesis in the BTBR mice (-) = decreased staining compared with B6; (0) = equal staining compared with B6; (+) = moderately increased staining compared with B6; (++) = strongly increased staining compared with B6.