Table 6 Power analysis referring to a family-based design for rare variants with high penetrance and a dominant model.
From: Candidate gene study of HOXB1 in autism spectrum disorder
Allele frequency | Penetrance | Power | ||
|---|---|---|---|---|
AA | AB | BB | ||
0.10 | 0.8 | 0.8 | 0.0 | 1.000 |
0.08 | 0.8 | 0.8 | 0.0 | 1.000 |
0.06 | 0.8 | 0.8 | 0.0 | 1.000 |
0.04 | 0.8 | 0.8 | 0.0 | 0.986 |
0.02 | 0.8 | 0.8 | 0.0 | 0.642 |
0.01 | 0.8 | 0.8 | 0.0 | 0.075 |
0.10 | 0.9 | 0.9 | 0.0 | 1.000 |
0.08 | 0.9 | 0.9 | 0.0 | 1.000 |
0.06 | 0.9 | 0.9 | 0.0 | 1.000 |
0.04 | 0.9 | 0.9 | 0.0 | 0.998 |
0.02 | 0.9 | 0.9 | 0.0 | 0.767 |
0.01 | 0.9 | 0.9 | 0.0 | 0.144 |
0.10 | 1.0 | 1.0 | 0.0 | 1.000 |
0.08 | 1.0 | 1.0 | 0.0 | 1.000 |
0.06 | 1.0 | 1.0 | 0.0 | 1.000 |
0.04 | 1.0 | 1.0 | 0.0 | 0.999 |
0.02 | 1.0 | 1.0 | 0.0 | 0.751 |
0.01 | 1.0 | 1.0 | 0.0 | 0.146 |