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Table 3 Interaction effect of BA and FS in relation to ASD

From: Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study

 

Odds ratios of exposure (95%CI)

Additive interaction (95%CI)e

Multiplicative interaction (95%CI)f

No BA/FS

BA

FS

BA and FS

AP

RERI

SI

Model 1a

1[Reference]

4.91(3.25–7.41)

***

3.68(1.87–7.22)

***

35.45(16.17–77.73)

***

0.79(0.46–0.89)

27.86(8.43-70.00)

5.23(2.09–13.09)

1.97(0.66–5.85)

Model 2b

1[Reference]

4.56(2.99–6.95)

***

3.22(1.57–6.58)

**

29.45(13.26–65.42)

***

0.77(0.40–0.88)

22.67(6.26–58.52)

4.93(1.91–12.73)

2.01(0.65–6.21)

Model 3c

1[Reference]

3.82(2.42–6.02)

***

3.06(1.48–6.31)

**

21.18(9.10–49.30)

***

0.72(0.24–0.86)

15.30(2.95–43.27)

4.14(1.49–11.46)

1.81(0.56–5.82)

Age (years)

        

3–7

1[Reference]

4.14(1.98–8.65)

***

0.86(0.12–6.28)

*

N/Ad

N/A

N/A

N/A

N/A

7–10

1[Reference]

4.78(2.40–9.52)

***

5.16(1.81–14.66)

**

67.47(20.61-220.84)

***

0.85(0.36–0.93)

46.83(8.04-173.02)

7.37(1.79–30.36)

2.74(0.51–14.63)

10–12

1[Reference]

2.17(0.73–6.50)

*

4.59(1.32–15.94)

**

28.22(6.68-119.23)

***

0.78(-0.28-0.90)

22.52(-1.26-113.61)

5.33(0.87–32.58)

2.83(0.34–23.43)

Sex

        

Boys

1[Reference]

2.86(1.63–5.03)

***

3.21(1.47-7.00)

**

15.65(5.80-42.21)

***

0.68(-0.08-0.83)

10.58(0.13–37.01)

3.60(1.04–12.51)

1.71(0.45–6.53)

Girls

1[Reference]

7.15(3.20-15.99)

***

1.72(0.23–13.17)

*

82.60(16.95-402.51)

***

0.90(0.36–0.95)

74.72(8.76-394.17)

11.87(1.95–72.24)

6.71(0.47–96.51)

  1. * P > 0.05, ** P < 0.05, *** P < 0.001; a Unadjusted; b Adjusted for demographic features such as age, sex, district, and income; c Further adjusted for demographic and BA, FS, ASD-related covariates, including age, sex, district, income, feeding practices, introverted father, paternal education level, maternal education level, maternal psychological status, and complications during pregnancy; d N/A denotes an insufficient sample size for result calculation; e The null hypothesis for each interaction: AP = 0, RERI = 0, SI = 1; f The null hypothesis for each interaction: the multiplicative interaction = 1 (All P > 0.05 in this multiplicative interaction analysis)