Fig. 1
From: Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons
Phosphorylated p38 level in the hypothalamus is significantly enhanced in ASD mouse model. A. KEGG enrichment analysis of the transcriptome from Shank3 knockdown primary neurons (GSE47150). B. KEGG enrichment analysis for the hypothalamus of Shank3TG mice (GSE120609). C. Overlapping of signaling pathways of two datasets, the number represents the well-defined pathways, and non-defined pathways were excluded. D. Immunoblotting and intensity of phosphorylation of p38, ERK1/2, and JNK in hypothalamus from WT and Shank3−/− mice (n = 3 per group). E. Immunoblotting and intensity of phosphorylated p38, ERK1/2, and JNK in hypothalamus from WT, BTBR mice (n = 3 per group). Statistical analysis: data were analyzed using unpaired two-tailed Student’s t-test (Prism9, GraphPad Software Inc.). Data were represented as Mean ± SD. Significance levels are indicated with *p < 0.05, **p < 0.01, ***p < 0.001