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Table 2 Meta-analyses results regarding resting-state functional and GMV difference between ASD and TD

From: Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder

Local Maximum

    

Cluster

 

Jackknife sensitivity

I2

Egger’s test

(p value)

Region

Peak MNI coordinate

(x, y, z)

SDM-Z value

p value

No. of voxels

Breakdown (No. of voxels)

Functional difference

ASD < TD

         

Left insula, BA 48

-40, -10, 10

-2.147

< 0.001

 

1156

Left insula, BA 48 (435)

Left rolandic operculum, BA 48 (255)

Left heschl gyrus, BA 48 (128)

Left superior temporal gyrus, BA 48 (88)

31/31

No (I2 < 50%)

0.190

Right superior frontal gyrus, medial, BA 10

4, 50 ,0

-1.738

< 0.001

 

385

Right superior frontal gyrus, medial, BA 10, 11 (225)

Left anterior cingulate / paracingulate gyri, BA 10, 32 (78)

Left superior frontal gyrus, medial, BA 10 (60)

Right anterior cingulate / paracingulate gyri, BA 10, 32 (17)

29/31

No (I2 < 50%)

0.857

Left angular gyrus, BA 39

-44, -56, 28

-1.712

< 0.001

 

76

Left angular gyrus, BA 39 (48)

29/31

No (I2 < 50%)

0.131

Right inferior temporal gyrus, BA 20

50, -2, -36

-1.471

0.003

 

63

Right inferior temporal gyrus, BA 20 (48)

Right temporal pole, middle temporal gyrus, BA 20, 21 (15)

25/31

No (I2 < 50%)

0.075

ASD > TD

         

Right supplementary motor area, BA 6, 11

8, 8, 52

1.138

0.002

 

239

Right supplementary motor area, BA 6, 8 (95)

30/31

No (I2 < 50%)

0.295

Right precuneus, BA 17, 18

10, -94, 4

1.150

0.002

 

73

Right precuneus, BA 17, 18 (59)

30/31

No (I2 < 50%)

0.949

GMV difference

         

ASD < TD

         

Left cerebellum, crus I

0, 40, 14

-1.383

< 0.001

 

653

Left cerebellum, crus I (287)

Left cerebellum, crus II (270)

Left cerebellum, hemispheric lobule VIIB (76)

56/57

No (I2 < 50%)

0.914

Left anterior cingulate / paracingulate gyri, BA 32

0, 40, 14

-1.204

0.001

 

187

Left anterior cingulate / paracingulate gyri, BA 24, 32 (141)

Left superior frontal gyrus, medial, BA 32 (8)

53/57

No (I2 < 50%)

0.804

Left anterior cingulate / paracingulate gyri

0, 0, 30

-1.338

< 0.001

 

97

Left anterior cingulate / paracingulate gyri (32)

Left median cingulate / paracingulate gyri 24, 23 (24)

Right median cingulate / paracingulate gyri 23, 24 (17)

54/57

No (I2 < 50%)

0.051

ASD > TD

         

Left middle temporal gyrus, BA 21

-60, -20, -14

1.807

< 0.001

 

789

Left middle temporal gyrus, BA 21, 20, 22, 48 (402)

Left insula, BA 48 (64)

Left superior temporal gyrus, BA 48 (61)

56/57

No (I2 < 50%)

0.095

Left olfactory cortex

-2, 20, -8

1.671

< 0.001

 

412

Left olfactory cortex, BA 25 (107)

Right olfactory cortex, BA 25 (60)

56/57

No (I2 < 50%)

0.425

Left middle temporal gyrus, BA 20

-46, 4, -26

1.640

< 0.001

 

181

Left middle temporal gyrus, BA 21 (83)

Left middle temporal gyrus, BA 20 (32)

56/57

No (I2 < 50%)

0.439

Right precentral gyrus

42, 2, 34

1.541

< 0.001

 

94

Right precentral gyrus, BA 6 (35)

54/57

No (I2 < 50%)

0.519

  1. Note: GMV = gray matter volume; ASD = autism spectrum disorder; TD = typically developing; MNI = Montreal Neurological Institute; SDM = seed-based d mapping; BA = Brodmann area
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Molecular Autism

ISSN: 2040-2392