Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder

Table 5 Brain-behavior correlations for fractional anisotropy (free-water corrected) in basal ganglia and cerebellar white matter tracts

Tract FA_T	ADI-R section C		RBS-R total		RBS-R stereotyped		RBS-R self-injury		RBS-R compulsive		RBS-R ritual		RBS-R sameness		RBS-R restricted interests		SCQ
Tract FA_T	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR
DLPFC to Caudate (L)	0.500	0.930	< 0.001	**0.003	0.004	*0.028	0.046	0.309	0.016	0.164	0.004	*0.043	< 0.001	**0.005	0.001	**0.005	0.021	0.211
DLPFC to Caudate (R)	0.029	0.288	0.025	0.063	0.006	*0.028	0.062	0.309	0.437	0.534	0.189	0.315	0.032	0.089	0.005	*0.026	0.441	0.773
M1U to Putamen (L)	0.168	0.839	0.187	0.268	0.367	0.459	0.779	0.918	0.289	0.413	0.770	0.770	0.250	0.312	0.053	0.076	0.696	0.773
M1U to Putamen (R)	0.930	0.930	0.565	0.628	0.617	0.617	0.892	0.918	0.164	0.354	0.411	0.587	0.817	0.817	0.829	0.829	0.637	0.773
SCP to M1U (L)	0.817	0.930	0.322	0.403	0.513	0.570	0.393	0.786	0.481	0.534	0.649	0.722	0.082	0.117	0.243	0.304	0.799	0.799
SCP to M1U (R)	0.661	0.930	0.741	0.741	0.341	0.459	0.918	0.918	0.922	0.922	0.635	0.722	0.329	0.366	0.778	0.829	0.566	0.773
SN to Putamen (L)	0.919	0.930	0.020	0.063	0.067	0.130	0.138	0.461	0.118	0.354	0.015	0.066	0.039	0.089	0.012	*0.039	0.208	0.773
SN to Putamen (R)	0.334	0.930	0.068	0.114	0.065	0.130	0.228	0.569	0.212	0.354	0.020	0.066	0.049	0.089	0.050	0.076	0.481	0.773
GPe to STN (L)	0.894	0.930	0.054	0.109	0.078	0.130	0.899	0.918	0.164	0.354	0.063	0.127	0.053	0.089	0.037	0.076	0.429	0.773
GPe to STN (R)	0.727	0.930	0.023	0.063	0.033	0.111	0.770	0.918	0.178	0.354	0.030	0.076	0.007	*0.036	0.041	0.076	0.318	0.773

Raw and FDR corrected p values from Spearman correlations between free-water corrected fractional anisotropy (FA_T) in basal ganglia and cerebellar tracts and behavioral measures. Measures of RRB included Section C of the Autism Diagnostic Interview-Revised (ADI-R), as well Repetitive Behavior Scale-Revised (RBS-R) total score and subsection scores. The Social Communication Questionnaire (SCQ) measures social and communication behaviors. Significant FDR corrected p values are bolded and indicated by *p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 2040-2392