Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder

Table 4 Free-water in basal ganglia and cerebellar white matter tracts

Tract FW	Mean ± Stdev		Diagnosis		Sex		Diagnosis * sex
Tract FW	ASD	TD	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR
DLPFC to Caudate (L)	0.227 ± 0.028	0.214 ± 0.025	0.002	*0.011	0.501	0.974	0.733	0.987
DLPFC to Caudate (R)	0.244 ± 0.037	0.230 ± 0.032	0.016	*0.041	0.920	0.974	0.533	0.987
M1U to Putamen (L)	0.205 ± 0.041	0.206 ± 0.052	0.611	0.763	0.507	0.974	0.632	0.987
M1U to Putamen (R)	0.212 ± 0.040	0.211 ± 0.047	0.915	0.915	0.974	0.974	0.291	0.727
SCP to M1U (L)	0.184 ± 0.027	0.185 ± 0.033	0.601	0.763	0.862	0.974	0.987	0.987
SCP to M1U (R)	0.197 ± 0.031	0.195 ± 0.030	0.914	0.915	0.724	0.974	0.945	0.987
SN to Putamen (L)	0.175 ± 0.024	0.164 ± 0.019	0.002	*0.011	0.633	0.974	0.282	0.727
SN to Putamen (R)	0.196 ± 0.029	0.185 ± 0.027	0.049	0.098	0.577	0.974	0.198	0.727
GPe to STN (L)	0.156 ± 0.029	0.145 ± 0.022	0.009	*0.031	0.361	0.974	0.224	0.727
GPe to STN (R)	0.165 ± 0.030	0.159 ± 0.031	0.344	0.574	0.635	0.974	0.793	0.987

Group means (± StDev), raw p values, and FDR corrected p values from 2 × 2 ANCOVA for free-water (FW) in each white matter tract, covaried for age and MRI scanner. Significant FDR corrected p values are bolded and indicated by *p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 2040-2392