Fig. 5
From: Tau reduction attenuates autism-like features in Fmr1 knockout mice
Genetically reducing Tau rescues impaired P38/MAPK signaling in Fmr1−/y mice. A, B GO process enrichment analysis based on DEGs identified in Fmr1−/y versus WT (A) and in Mapt± versus WT (B) groups. Red ones indicate GO processes shared in (A) and (B). C–E Equal amounts of protein lysates from mouse cortical tissues were analyzed by western blotting for indicated proteins (C). Levels of phosphorylated p38 (D) and ERK (E) in different groups of mice (FVB;C57BL/6/SV129 mixed background, 2.5-month-old) were normalized to respective total protein levels for comparison. One-way ANOVA with Tukey’s post hoc test. WT: n = 6; Mapt±: n = 6; Fmr1−/y: n = 6; Fmr1−/y;Mapt±: n = 6. ns: not significant; *p < 0.05, **p < 0.01, ***p < 0.001